Literature DB >> 1335251

A carboline derivative as a novel mammalian DNA topoisomerase II targeting agent.

F Pognan1, J M Saucier, C Paoletti, L Kaczmarek, P Nantka-Namirski, M Mordarski, W Peczynska-Czoch.   

Abstract

The DNA intercalating, ellipticine analog drug, 5,11-dimethyl-5H-indol[2,3-b]quinoline, is able to stabilize in vitro the topoisomerase II-DNA cleavable complex and to induce DNA breaks in BPV I episome in rat fibroblasts. Cytotoxicity studies with DC3F cells resistant to ellipticine strongly suggest that topoisomerase II is a cellular target involved in the mechanism of cytotoxic action of this carboline derivative.

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Year:  1992        PMID： 1335251     DOI： 10.1016/0006-2952(92)90341-f

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  4 in total

1.  Synthesis of peptidomimetics using a polymer-bound Boc-linker.

Authors:  T Redemann; H Bandel; G Jung
Journal:  Mol Divers       Date:  1998       Impact factor: 2.943

Review 2.  Recent trends in targeted anticancer prodrug and conjugate design.

Authors:  Yashveer Singh; Matthew Palombo; Patrick J Sinko
Journal:  Curr Med Chem       Date:  2008       Impact factor: 4.530

Review 3.  Comprehensive review of α-carboline alkaloids: Natural products, updated synthesis, and biological activities.

Authors:  Deping Li; Renze Yang; Jun Wu; Bin Zhong; Yan Li
Journal:  Front Chem       Date:  2022-08-26       Impact factor: 5.545

4.  Synthesis of novel indolo[3,2-c]isoquinoline derivatives bearing pyrimidine, piperazine rings and their biological evaluation and docking studies against COVID-19 virus main protease.

Authors:  Vaijinath A Verma; Anand R Saundane; Rajkumar S Meti; Dushyanth R Vennapu
Journal:  J Mol Struct       Date:  2020-12-27       Impact factor: 3.196
  4 in total

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