| Literature DB >> 1335079 |
T R Bailey1, G D Diana, P J Kowalczyk, V Akullian, M A Eissenstat, D Cutcliffe, J P Mallamo, P M Carabateas, D C Pevear.
Abstract
A variety of heterocyclic analogs of Win 54954 have been synthesized and tested in vitro against human rhinovirus type 14 (HRV-14) in a plaque reduction assay. The more active compounds were tested against 14 additional serotypes, and the concentration which inhibited 80% of the serotypes tested (MIC80) was measured. One compound, 37, exhibited activity comparable to Win 59454. Physicochemical as well as electrostatic parameters were calculated and the results subjected to a QSAR analysis in an effort to explain differences in activity observed between these compounds; however, no meaningful correlation with biological activity was found with any of these parameters.Entities:
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Year: 1992 PMID： 1335079 DOI： 10.1021/jm00102a017
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446