Literature DB >> 1335019

Effects of tetanus toxin, Salmonella typhimurium porin, and bacterial lipopolysaccharide on platelet aggregation.

C Matera1, C Falzarano, L Berrino, F Rossi.   

Abstract

Endotoxins may interfere with platelet aggregation by interacting with the platelet membrane. The aim of this study was to evaluate the effects of tetanus toxin, Salmonella typhimurium porin, and bacterial lipopolysaccharide (LPS) on platelet aggregation induced by ADP and thrombin in vitro. Spontaneous platelet aggregation and platelet aggregation induced by ADP and thrombin were measured. Our results show that Salmonella typhimurium porin and bacterial LPS enhanced human and rabbit platelet aggregation induced by ADP and thrombin. Tetanus toxin did not affect platelet aggregation.

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Year:  1992        PMID: 1335019

Source DB:  PubMed          Journal:  J Med        ISSN: 0025-7850


  5 in total

Review 1.  Platelets and innate immunity.

Authors:  John W Semple; John Freedman
Journal:  Cell Mol Life Sci       Date:  2009-12-18       Impact factor: 9.261

2.  Platelet reactivity in sepsis syndrome: results from the PRESS study.

Authors:  Karolina Akinosoglou; Spyridoula Theodoraki; Ioanna Xanthopoulou; Angelos Perperis; Theologia Gkavogianni; Aikaterini Pistiki; Evangelos Giamarellos-Bourboulis; Charalambos A Gogos
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2017-08-24       Impact factor: 3.267

Review 3.  The role of inflammation in regulating platelet production and function: Toll-like receptors in platelets and megakaryocytes.

Authors:  Lea M Beaulieu; Jane E Freedman
Journal:  Thromb Res       Date:  2009-11-27       Impact factor: 3.944

4.  Aggregation and microparticle production through toll-like receptor 4 activation in platelets from recently menopausal women.

Authors:  Kazunori Hashimoto; Muthuvel Jayachandran; Whyte G Owen; Virginia M Miller
Journal:  J Cardiovasc Pharmacol       Date:  2009-07       Impact factor: 3.105

5.  Attenuated platelet aggregation in patients with septic shock is independent from the activity state of myosin light chain phosphorylation or a reduction in Rho kinase-dependent inhibition of myosin light chain phosphatase.

Authors:  Benjamin Aj Reddi; Samantha M Iannella; Stephanie N O'Connor; Adam M Deane; Scott R Willoughby; David P Wilson
Journal:  Intensive Care Med Exp       Date:  2015-02-12
  5 in total

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