Literature DB >> 1334890

The effect of IL-6 on the des-gamma-carboxy prothrombin synthesis in human hepatoma cells.

M Ono1, H Kohda, T Naraki, H Ohta, M Ohhira, C Sekiya, M Namiki.   

Abstract

Effects of several cytokines on des-gamma-carboxy prothrombin (PIVKA II) synthesis in human hepatoma cells were investigated to know the process of PIVKA II production during a liver allograft rejection. Human recombinant interleukin-6 (IL-6) significantly stimulated the PIVKA II synthesis without any influence on the cell proliferation. The effect was almost completely neutralized by the specific anti-IL-6 antibody. Neither tumor necrosis factor (TNF), interleukin-1 (IL-1) nor interferon-gamma (IFN-gamma) had such a stimulative effect. IL-6 appears to stimulate PIVKA II production, and would be a candidate of factors that enhance the production of PIVKA II during a liver allograft rejection.

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Year:  1992        PMID： 1334890     DOI： 10.1007/bf02806527

Source DB:  PubMed          Journal:  Gastroenterol Jpn        ISSN： 0435-1339


  22 in total

1.  Construction of rat-mouse T cell hybridomas that express regulatable rat interleukin 2 receptor.

Authors:  H Kohda; T Uede; H Yuasa; T Yamaki; H Osawa; T Diamantstein; J Yodoi; K Kikuchi
Journal:  J Immunol       Date:  1986-09-01       Impact factor: 5.422

2.  Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.

Authors:  J Gauldie; C Richards; D Harnish; P Lansdorp; H Baumann
Journal:  Proc Natl Acad Sci U S A       Date:  1987-10       Impact factor: 11.205

Review 3.  Vitamin K-dependent carboxylase.

Authors:  J W Suttie
Journal:  Annu Rev Biochem       Date:  1985       Impact factor: 23.643

4.  Production of HBs-antigen by two new human hepatoma cell lines and its enhancement by dexamethasone.

Authors:  N Huh; T Utakoji
Journal:  Gan       Date:  1981-02

5.  Detection of vitamin K deficiency by use of an enzyme-linked immunosorbent assay for circulating abnormal prothrombin.

Authors:  K Motohara; Y Kuroki; H Kan; F Endo; I Matsuda
Journal:  Pediatr Res       Date:  1985-04       Impact factor: 3.756

6.  Tumor necrosis factor-alpha inhibits 1,25-dihydroxyvitamin D3-stimulated bone Gla protein synthesis in rat osteosarcoma cells (ROS 17/2.8) by a pretranslational mechanism.

Authors:  M S Nanes; J Rubin; L Titus; G N Hendy; B Catherwood
Journal:  Endocrinology       Date:  1991-05       Impact factor: 4.736

7.  Evidence that production of interleukin 6 within the rejecting allograft coincides with cytotoxic T lymphocyte development.

Authors:  H R Ford; R A Hoffman; D J Tweardy; P Kispert; S Wang; R L Simmons
Journal:  Transplantation       Date:  1991-03       Impact factor: 4.939

8.  Measurement of immunoreactive prothrombin precursor and vitamin-K-dependent gamma-carboxylation in human hepatocellular carcinoma tissues: decreased carboxylation of prothrombin precursor as a cause of des-gamma-carboxyprothrombin synthesis.

Authors:  M Ono; H Ohta; M Ohhira; C Sekiya; M Namiki
Journal:  Tumour Biol       Date:  1990

9.  Chemical modification of gamma-carboxyglutamic acid residues in prothrombin elicits a conformation similar to that of abnormal (des-gamma-carboxy)prothrombin.

Authors:  T Sugo; K Watanabe; T Naraki; M Matsuda
Journal:  J Biochem       Date:  1990-09       Impact factor: 3.387

10.  Purification and NH2-terminal sequence of a plasmacytoma growth factor derived from the murine macrophage cell line P388D1.

Authors:  R P Nordan; J G Pumphrey; S Rudikoff
Journal:  J Immunol       Date:  1987-08-01       Impact factor: 5.422
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