Literature DB >> 133475

The oral toxicity of clioquinol (5-chloro-7-iodo-8-hydroxyquinoline) in beagle dogs.

R Heywood, H Chesterman, A N Worden.   

Abstract

When clioquinol was administered to Beagle dogs, disturbances in gait which were associated with abnormal reflexes and reactions, were seen in animals receiving 250 and 400 mg/kg body weight per day. Histopathological examination of the central nervous system (CNS) showed pathological change in the posterior columns of the spinal cord.

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Year:  1976        PMID: 133475     DOI: 10.1016/0300-483x(76)90006-8

Source DB:  PubMed          Journal:  Toxicology        ISSN: 0300-483X            Impact factor:   4.221


  2 in total

1.  Clioquinol and 2,5-hexanedione induce different types of distal axonopathy in the dog.

Authors:  G Krinke; H H Schaumburg; P S Spencer; P Thomann; R Hess
Journal:  Acta Neuropathol       Date:  1979-08       Impact factor: 17.088

Review 2.  Behavioral toxicology, risk assessment, and chlorinated hydrocarbons.

Authors:  A M Evangelista de Duffard; R Duffard
Journal:  Environ Health Perspect       Date:  1996-04       Impact factor: 9.031

  2 in total

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