Literature DB >> 1334412

Purification and characterization of phosphatidylinositol 4-phosphate 5-kinases.

N Divecha1, C E Brooksbank, R F Irvine.   

Abstract

We detail the purification and characterization of three distinct isoforms of PtdIns4P 5-kinase present in bovine brain. One of these, PtdIns4P 5-kinase C, was purified to apparent homogeneity, and SDS/PAGE analysis demonstrated a single polypeptide and molecular mass 53 KDa. These three isoforms were shown to differ in their kinetic properties, and immunological characterization with an antibody raised to PtdIns4P 5-kinase C demonstrated that this isoform was unrelated to the other two. Furthermore, PtdIns4P 5-kinase C was shown to be the bovine brain homologue of the Type II PtdIns4P 5-kinase previously purified from human erythrocytes [Bazenet, Ruano, Brockman & Anderson (1990) J. Biol. Chem. 265, 18012-18022].

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Year:  1992        PMID： 1334412      PMCID： PMC1132058          DOI： 10.1042/bj2880637

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  25 in total

Review 1.  Inositol phosphates and cell signalling.

Authors:  M J Berridge; R F Irvine
Journal:  Nature       Date:  1989-09-21       Impact factor: 49.962

Review 2.  The role of protein kinase C in cell surface signal transduction and tumour promotion.

Authors:  Y Nishizuka
Journal:  Nature       Date:  1984 Apr 19-25       Impact factor: 49.962

3.  Inhibition of phosphatidylinositol-4-phosphate kinase by its product phosphatidylinositol-4,5-bisphosphate.

Authors:  L A Van Rooijen; M Rossowska; N G Bazan
Journal:  Biochem Biophys Res Commun       Date:  1985-01-16       Impact factor: 3.575

4.  Purification and characterization of phosphoinositide 3-kinase from rat liver.

Authors:  C L Carpenter; B C Duckworth; K R Auger; B Cohen; B S Schaffhausen; L C Cantley
Journal:  J Biol Chem       Date:  1990-11-15       Impact factor: 5.157

5.  Regulation of brain phosphatidylinositol-4-phosphate kinase by GTP analogues. A potential role for guanine nucleotide regulatory proteins.

Authors:  C D Smith; K J Chang
Journal:  J Biol Chem       Date:  1989-02-25       Impact factor: 5.157

6.  Polyphosphoinositide synthesis in platelets stimulated with low concentrations of thrombin is enhanced before the activation of phospholipase C.

Authors:  I Lassing; U Lindberg
Journal:  FEBS Lett       Date:  1990-03-26       Impact factor: 4.124

7.  Chemoattractants stimulate phosphatidylinositol-4-phosphate kinase in human polymorphonuclear leukocytes.

Authors:  M C Pike; M E Bruck; C Arndt; C S Lee
Journal:  J Biol Chem       Date:  1990-02-05       Impact factor: 5.157

8.  Interaction between the epidermal growth factor receptor and phosphoinositide kinases.

Authors:  C Cochet; O Filhol; B Payrastre; T Hunter; G N Gill
Journal:  J Biol Chem       Date:  1991-01-05       Impact factor: 5.157

9.  Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils.

Authors:  L R Stephens; K T Hughes; R F Irvine
Journal:  Nature       Date:  1991-05-02       Impact factor: 49.962

10.  Platelet-derived growth factor stimulates synthesis of PtdIns(3,4,5)P3 by activating a PtdIns(4,5)P2 3-OH kinase.

Authors:  P T Hawkins; T R Jackson; L R Stephens
Journal:  Nature       Date:  1992-07-09       Impact factor: 49.962
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  10 in total

1.  Monoclonal antibodies to phosphatidylinositol 4-phosphate 5-kinase: distribution and intracellular localization of the C isoform.

Authors:  C E Brooksbank; A Hutchings; G W Butcher; R F Irvine; N Divecha
Journal:  Biochem J       Date:  1993-04-01       Impact factor: 3.857

2.  Phosphoinositide signalling enzymes in rat liver nuclei: phosphoinositidase C isoform beta 1 is specifically, but not predominantly, located in the nucleus.

Authors:  N Divecha; S G Rhee; A J Letcher; R F Irvine
Journal:  Biochem J       Date:  1993-02-01       Impact factor: 3.857

3.  Regulation of PtdIns4P 5-kinase C by thrombin-stimulated changes in its phosphorylation state in human platelets.

Authors:  K A Hinchliffe; R F Irvine; N Divecha
Journal:  Biochem J       Date:  1998-01-01       Impact factor: 3.857

4.  Metabolism and possible compartmentalization of inositol lipids in isolated rat-liver nuclei.

Authors:  L R Vann; F B Wooding; R F Irvine; N Divecha
Journal:  Biochem J       Date:  1997-10-15       Impact factor: 3.857

5.  Aggregation-dependent, integrin-mediated increases in cytoskeletally associated PtdInsP2 (4,5) levels in human platelets are controlled by translocation of PtdIns 4-P 5-kinase C to the cytoskeleton.

Authors:  K A Hinchliffe; R F Irvine; N Divecha
Journal:  EMBO J       Date:  1996-12-02       Impact factor: 11.598

6.  Activation of phosphatidylinositol 4,5-bisphosphate supply by agonists and non-hydrolysable GTP analogues.

Authors:  L Stephens; T R Jackson; P T Hawkins
Journal:  Biochem J       Date:  1993-12-01       Impact factor: 3.857

Review 7.  Phosphoinositides: tiny lipids with giant impact on cell regulation.

Authors:  Tamas Balla
Journal:  Physiol Rev       Date:  2013-07       Impact factor: 37.312

8.  Specific binding sites for inositol 1,3,4,5-tetrakisphosphate are located predominantly in the plasma membranes of human platelets.

Authors:  P J Cullen; Y Patel; V V Kakkar; R F Irvine; K S Authi
Journal:  Biochem J       Date:  1994-03-15       Impact factor: 3.857

9.  The cloning and sequence of the C isoform of PtdIns4P 5-kinase.

Authors:  N Divecha; O Truong; J J Hsuan; K A Hinchliffe; R F Irvine
Journal:  Biochem J       Date:  1995-08-01       Impact factor: 3.857

10.  A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development.

Authors:  K Zhou; K Takegawa; S D Emr; R A Firtel
Journal:  Mol Cell Biol       Date:  1995-10       Impact factor: 4.272
  10 in total

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