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Literature DB >> 1334049

Mucosal protective activity of prostaglandin analogs in rodent colonic inflammation.

D J Fretland¹, D L Widomski, C P Anglin, R E Walsh, S Levin, A F Gasiecki, P W Collins.

Abstract

The mucosal protective prostaglandin analogs misoprostol, enisoprost, and SC-46275 (the 17E-18-cyclopentenyl analog of enisoprost) were tested in mouse and rat colitis induced by the intrarectal instillation of dilute acetic acid. Colitis was assessed by histology and colonic levels of myeloperoxidase (a neutrophil marker enzyme). When given as enemas 30 min ahead of colitis induction, 15(R)-15-methyl-PGE2 (arbaprostil) and 15(S)-15-methyl-PGE1 were inactive; however, misoprostol, enisoprost, and SC-46275 protected against colonic inflammation with ED50 values of 24, 12 and 1.3 micrograms/kg, respectively, in rats and 11, 5, and 1 micrograms/kg, respectively, in mice. These compounds may have utility in the medical management of human inflammatory bowel disease.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1992 PMID： 1334049 DOI： 10.1007/bf00919345

Source DB: PubMed Journal: Inflammation ISSN： 0360-3997 Impact factor: 4.092

15 in total

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Authors: R N Fedorak; L R Empey; C MacArthur; L D Jewell
Journal: Gastroenterology Date: 1990-03 Impact factor: 22.682

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Journal: Adv Immunol Date: 1988 Impact factor: 3.543

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Authors: H Allgayer; K Deschryver; W F Stenson
Journal: Gastroenterology Date: 1989-05 Impact factor: 22.682

5. Relationship between arachidonic acid metabolism, myeloperoxidase activity and leukocyte infiltration in a rat model of inflammatory bowel disease.

Authors: N K Boughton-Smith; J L Wallace; B J Whittle
Journal: Agents Actions Date: 1988-08

6. Misoprostol therapy following trinitrobenzene sulfonic acid-induced colitis accelerates healing.

Authors: K J Torsher; L R Empey; R N Fedorak
Journal: Prostaglandins Leukot Essent Fatty Acids Date: 1992-04 Impact factor: 4.006

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Authors: D J Fretland; S Levin; B S Tsai; S W Djurić; D L Widomski; J M Zemaitis; R L Shone; R F Bauer
Journal: Agents Actions Date: 1989-06

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Authors: J E Krawisz; P Sharon; W F Stenson
Journal: Gastroenterology Date: 1984-12 Impact factor: 22.682

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Authors: E Goldin; D Rachmilewitz
Journal: Dig Dis Sci Date: 1983-09 Impact factor: 3.199

3. Pharmacological activity of the second generation leukotriene B4 receptor antagonist, SC-53228: effects on acute colonic inflammation and hepatic function in rodents.

Authors: D J Fretland; C P Anglin; D Widomski; D A Baron; T Maziasz; P F Smith
Journal: Inflammation Date: 1995-10 Impact factor: 4.092

3 in total