Literature DB >> 1332577

Orthotopic reconstitution of human small-cell lung carcinoma after intravenous transplantation in SCID mice.

T H Kuo1, T Kubota, M Watanabe, T Furukawa, S Kase, H Tanino, H Nishibori, Y Saikawa, T Teramoto, K Ihsibiki.   

Abstract

We have constructed an orthotopically reconstituted model of human small-cell lung carcinoma (SCLC) by intravenous transplantation in severe combined immunodeficient (SCID) mice. Two human SCLC xenografts, H-69 and Lu-130, were disaggregated and injected through the tail vein of SCID mice. Human SCLCs were orthotopically reconstituted with multi-focal lung tumor growth in all SCID mice after intravenous injection of 5 x 10(6) tumor cells per mouse. The heart and liver were also seeded with actively growing SCLC. This orthotopic reconstitution model of human SCLC in SCID mice should be useful for further studies on the biological behavior and treatment of human SCLC.

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Year:  1992        PMID： 1332577

Source DB:  PubMed          Journal:  Anticancer Res        ISSN： 0250-7005            Impact factor:   2.480


  7 in total

Review 1.  Mesenchymal stem cell-based tumor-targeted gene therapy in gastrointestinal cancer.

Authors:  Qi Bao; Yue Zhao; Hanno Niess; Claudius Conrad; Bettina Schwarz; Karl-Walter Jauch; Ralf Huss; Peter J Nelson; Christiane J Bruns
Journal:  Stem Cells Dev       Date:  2012-06-26       Impact factor: 3.272

2.  Targeted cytosine deaminase-uracil phosphoribosyl transferase suicide gene therapy induces small cell lung cancer-specific cytotoxicity and tumor growth delay.

Authors:  Camilla L Christensen; Torben Gjetting; Thomas T Poulsen; Frederik Cramer; Jack A Roth; Hans S Poulsen
Journal:  Clin Cancer Res       Date:  2010-04-06       Impact factor: 12.531

3.  Characterization of a highly metastatic, orthotopic lung cancer model in the nude rat.

Authors:  R B Howard; J B Mullen; M E Pagura; M R Johnston
Journal:  Clin Exp Metastasis       Date:  1999-03       Impact factor: 5.150

Review 4.  Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinic.

Authors:  R M Hoffman
Journal:  Invest New Drugs       Date:  1999       Impact factor: 3.850

5.  Interleukin-11 Receptor Is a Candidate Target for Ligand-Directed Therapy in Lung Cancer: Analysis of Clinical Samples and BMTP-11 Preclinical Activity.

Authors:  Marina Cardó-Vila; Serena Marchiò; Masanori Sato; Fernanda I Staquicini; Tracey L Smith; Julianna K Bronk; Guosheng Yin; Amado J Zurita; Menghong Sun; Carmen Behrens; Richard L Sidman; J Jack Lee; Waun K Hong; Ignacio I Wistuba; Wadih Arap; Renata Pasqualini
Journal:  Am J Pathol       Date:  2016-06-16       Impact factor: 4.307

6.  Liver colonization competence governs colon cancer metastasis.

Authors:  T H Kuo; T Kubota; M Watanabe; T Furukawa; T Teramoto; K Ishibiki; M Kitajima; A R Moossa; S Penman; R M Hoffman
Journal:  Proc Natl Acad Sci U S A       Date:  1995-12-19       Impact factor: 11.205

Review 7.  Small-cell lung cancer-associated autoantibodies: potential applications to cancer diagnosis, early detection, and therapy.

Authors:  Meleeneh Kazarian; Ite A Laird-Offringa
Journal:  Mol Cancer       Date:  2011-03-30       Impact factor: 27.401
  7 in total

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