Literature DB >> 1332038

Conservation of structure and function of DNA replication protein A in the trypanosomatid Crithidia fasciculata.

G W Brown1, T E Melendy, D S Ray.   

Abstract

Human replication protein A (RP-A) is a three-subunit protein that is required for simian virus 40 (SV40) replication in vitro. The trypanosome homologue of RP-A has been purified from Crithidia fasciculata. It is a 1:1:1 complex of three polypeptides of 51, 28, and 14 kDa, binds single-stranded DNA via the large subunit, and is localized within the nucleus. C. fasciculata RP-A substitutes for human RP-A in the large tumor antigen-dependent unwinding of the SV40 origin of replication and stimulates both DNA synthesis and DNA priming by human DNA polymerase alpha/primase, but it does not support efficient SV40 DNA replication in vitro. This extraordinary conservation of structure and function between human and trypanosome RP-A suggests that the mechanism of DNA replication, at both the initiation and the elongation level, is conserved in organisms that diverged from the main eukaryotic lineage very early in evolution.

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Year:  1992        PMID： 1332038      PMCID： PMC50311          DOI： 10.1073/pnas.89.21.10227

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  33 in total

1.  Cell-cycle-regulated phosphorylation of DNA replication factor A from human and yeast cells.

Authors:  S Din; S J Brill; M P Fairman; B Stillman
Journal:  Genes Dev       Date:  1990-06       Impact factor: 11.361

Review 2.  Early evolution and the origin of eukaryotes.

Authors:  M L Sogin
Journal:  Curr Opin Genet Dev       Date:  1991-12       Impact factor: 5.578

Review 3.  Replication of kinetoplast DNA in trypanosomes.

Authors:  K A Ryan; T A Shapiro; C A Rauch; P T Englund
Journal:  Annu Rev Microbiol       Date:  1988       Impact factor: 15.500

Review 4.  Kinetoplast DNA minicircles: high-copy-number mitochondrial plasmids.

Authors:  D S Ray
Journal:  Plasmid       Date:  1987-05       Impact factor: 3.466

5.  Initiation of simian virus 40 DNA replication in vitro: large-tumor-antigen- and origin-dependent unwinding of the template.

Authors:  M S Wold; J J Li; T J Kelly
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

6.  Novobiocin affinity purification of a mitochondrial type II topoisomerase from the trypanosomatid Crithidia fasciculata.

Authors:  T Melendy; D S Ray
Journal:  J Biol Chem       Date:  1989-01-25       Impact factor: 5.157

7.  Multiple functions of human single-stranded-DNA binding protein in simian virus 40 DNA replication: single-strand stabilization and stimulation of DNA polymerases alpha and delta.

Authors:  M K Kenny; S H Lee; J Hurwitz
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

8.  Yeast replication factor-A functions in the unwinding of the SV40 origin of DNA replication.

Authors:  S J Brill; B Stillman
Journal:  Nature       Date:  1989-11-02       Impact factor: 49.962

9.  Replication factor-A from Saccharomyces cerevisiae is encoded by three essential genes coordinately expressed at S phase.

Authors:  S J Brill; B Stillman
Journal:  Genes Dev       Date:  1991-09       Impact factor: 11.361

10.  Cellular factors required for multiple stages of SV40 DNA replication in vitro.

Authors:  M P Fairman; B Stillman
Journal:  EMBO J       Date:  1988-04       Impact factor: 11.598
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  11 in total

1.  Characterization of the Crithidia fasciculata mRNA cycling sequence binding proteins.

Authors:  R Mahmood; B Mittra; J C Hines; D S Ray
Journal:  Mol Cell Biol       Date:  2001-07       Impact factor: 4.272

2.  Mitochondrial histone-like DNA-binding proteins are essential for normal cell growth and mitochondrial function in Crithidia fasciculata.

Authors:  Nuraly K Avliyakulov; Julius Lukes; Dan S Ray
Journal:  Eukaryot Cell       Date:  2004-04

3.  Saccharomyces cerevisiae replication protein A binds to single-stranded DNA in multiple salt-dependent modes.

Authors:  Sangaralingam Kumaran; Alexander G Kozlov; Timothy M Lohman
Journal:  Biochemistry       Date:  2006-10-03       Impact factor: 3.162

4.  Cell cycle regulation of RPA1 transcript levels in the trypanosomatid Crithidia fasciculata.

Authors:  L M Brown; D S Ray
Journal:  Nucleic Acids Res       Date:  1997-08-15       Impact factor: 16.971

5.  Disruption of the Crithidia fasciculata RNH1 gene results in the loss of two active forms of ribonuclease H.

Authors:  D S Ray; J C Hines
Journal:  Nucleic Acids Res       Date:  1995-07-11       Impact factor: 16.971

6.  Phosphorylation of human replication protein A by the DNA-dependent protein kinase is involved in the modulation of DNA replication.

Authors:  L A Henricksen; T Carter; A Dutta; M S Wold
Journal:  Nucleic Acids Res       Date:  1996-08-01       Impact factor: 16.971

7.  Species-specific functional interactions of DNA polymerase alpha-primase with simian virus 40 (SV40) T antigen require SV40 origin DNA.

Authors:  C Schneider; K Weisshart; L A Guarino; I Dornreiter; E Fanning
Journal:  Mol Cell Biol       Date:  1994-05       Impact factor: 4.272

8.  Rpa4, a homolog of the 34-kilodalton subunit of the replication protein A complex.

Authors:  K F Keshav; C Chen; A Dutta
Journal:  Mol Cell Biol       Date:  1995-06       Impact factor: 4.272

9.  Functional complementation of an Escherichia coli ribonuclease H mutation by a cloned genomic fragment from the trypanosomatid Crithidia fasciculata.

Authors:  A G Campbell; D S Ray
Journal:  Proc Natl Acad Sci U S A       Date:  1993-10-15       Impact factor: 11.205

10.  Leishmania braziliensis replication protein A subunit 1: molecular modelling, protein expression and analysis of its affinity for both DNA and RNA.

Authors:  Paola A Nocua; Cesar A Ramirez; George E Barreto; Janneth González; José M Requena; Concepción J Puerta
Journal:  Parasit Vectors       Date:  2014-12-12       Impact factor: 3.876
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