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Literature DB >> 1331897

Detection of JC virus in the brains of aged patients without progressive multifocal leukoencephalopathy by the polymerase chain reaction and Southern hybridization analysis.

M Mori¹, N Aoki, H Shimada, M Tajima, K Kato.

Abstract

Ninety-one brain tissue sections taken at autopsy from 33 elderly patients (63-100 years old) without progressive multifocal leukoencephalopathy were examined for the presence of JC virus DNA by the polymerase chain reaction and Southern hybridization analysis after DNA extraction. JC virus DNA was detected in 15 sections from 10 patients. These results suggest that JC virus is frequently present in the brains of aged patients.

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Year: 1992 PMID： 1331897 DOI： 10.1016/0304-3940(92)90883-9

Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046

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Cited

19 in total

1. Latency and reactivation of JC virus in peripheral blood of human immunodeficiency virus type 1-infected patients.

Authors: V Dubois; H Dutronc; M E Lafon; V Poinsot; J L Pellegrin; J M Ragnaud; A M Ferrer; H J Fleury
Journal: J Clin Microbiol Date: 1997-09 Impact factor: 5.948

2. Role for tumor necrosis factor-α in JC virus reactivation and progressive multifocal leukoencephalopathy.

Authors: Hassen S Wollebo; Mahmut Safak; Luis Del Valle; Kamel Khalili; Martyn K White
Journal: J Neuroimmunol Date: 2010-12-24 Impact factor: 3.478

3. Natalizumab in the treatment of multiple sclerosis.

Authors: Ozgür Yaldizli; Norman Putzki
Journal: Ther Adv Neurol Disord Date: 2009-03 Impact factor: 6.570

4. Risk of Biologic Therapy-Associated Progressive Multifocal Leukoencephalopathy: Use of the JC Virus Antibody Assay in the Treatment of Moderate-to-Severe Crohn's Disease.

Authors: Gary R Lichtenstein; Stephen B Hanauer; William J Sandborn
Journal: Gastroenterol Hepatol (N Y) Date: 2012-11

Detection of JC virus in the brains of aged patients without progressive multifocal leukoencephalopathy by the polymerase chain reaction and Southern hybridization analysis.

1. Latency and reactivation of JC virus in peripheral blood of human immunodeficiency virus type 1-infected patients.

2. Role for tumor necrosis factor-α in JC virus reactivation and progressive multifocal leukoencephalopathy.

3. Natalizumab in the treatment of multiple sclerosis.

4. Risk of Biologic Therapy-Associated Progressive Multifocal Leukoencephalopathy: Use of the JC Virus Antibody Assay in the Treatment of Moderate-to-Severe Crohn's Disease.

5. Cooperative roles of NF-κB and NFAT4 in polyomavirus JC regulation at the KB control element.

6. Detection of reactivation and size variation in the regulatory region of JC virus in brain tissue.

7. The 50th birthday of progressive multifocal leukoencephalopathy: New insights into pathogenesis.

Review 8. The role of polyomaviruses in human disease.

Review 9. The evolution of small DNA viruses of eukaryotes: past and present considerations.

10. Detection of JC virus DNA fragments but not proteins in normal brain tissue.