Apo AIV in plasma and dialysate fluid of CAPD patients: comparison with other apolipoproteins.

Plasma lipids and apolipoproteins were determined in 18 patients with chronic renal failure on haemodialysis (HD), 18 patients on continuous ambulatory peritoneal dialysis (CAPD), and 18 healthy controls. Significant differences were observed between the two dialysis procedures, CAPD patients showed elevated plasma cholesterol, apo AI and apoB. No significant difference in plasma apo AIV concentration was observed between the two dialysis groups. Measurement of apolipoproteins in the dialysate fluid of five patients on CAPD showed losses of all apolipoproteins (AI, AII, AIV, B, CII, CIII and E). Although daily losses of apo AI and apo AIV were similar (255 and 221 mg/day respectively), the peritoneal clearance of apo AIV was threefold that of apo AI and 12-fold that of apo B. In view of the inverse correlation between peritoneal clearance and the molecular mass of proteins, about 13% of total plasma apo AIV was lost daily as lipoprotein-free form.