Literature DB >> 13317

Analysis of the actions of cimetidine and metiamide on gastric acid secretion in the isolated guinea pig gastric mucosa.

S E Sjöstrand, B Ryberg, L Olbe.   

Abstract

Cumulative dose-response curves for histamine were determined on acid secretion from the isolated guinea pig gastric mucosa. Two H2-receptor antagonists-metiamide and cimetidine-behaved like competitive antagonists to histamine on gastric acid secretion in vitro. The isolated guinea pig gastric mucosa seems to be a suitable in vitro model for analysing the action of compounds on receptors involved in acid secretion.

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Year:  1977        PMID： 13317     DOI： 10.1007/BF00508465

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  3 in total

1.  Studies on gastric acid secretion using an isolated whole mammalian stomach in vitro.

Authors:  M E Parsons
Journal:  J Physiol       Date:  1975-05       Impact factor: 5.182

2.  Metiamide--an orally active histamine H2-receptor antagonist.

Authors:  J W Black; W A Duncan; J C Emmett; C R Ganellin; T Hesselbo; M E Parsons; J H Wyllie
Journal:  Agents Actions       Date:  1973-10

3.  Inhibition of in vitro stimulated gastric acid secretion by a histamine H2-receptor antagonist, metiamide.

Authors:  B Y Wan; E S Assem; H O Schild
Journal:  Eur J Pharmacol       Date:  1974-11       Impact factor: 4.432
  3 in total
  7 in total

1.  Comparative assay of histamine H2-receptor antagonists using the isolated mouse stomach [proceedings].

Authors:  J A Angus; J W Black; M Stone
Journal:  Br J Pharmacol       Date:  1978-03       Impact factor: 8.739

2.  Acid stimulated alkaline secretion in the rabbit duodenum is passive and correlates with mucosal damage.

Authors:  P Vattay; W Feil; S Klimesch; E Wenzl; M Starlinger; R Schiessel
Journal:  Gut       Date:  1988-03       Impact factor: 23.059

3.  Further analysis of anomalous pKB values for histamine H2-receptor antagonists on the mouse isolated stomach assay.

Authors:  J W Black; P Leff; N P Shankley
Journal:  Br J Pharmacol       Date:  1985-11       Impact factor: 8.739

4.  Pharmacological analysis of the pentagastrin-tiotidine interaction in the mouse isolated stomach.

Authors:  J W Black; P Leff; N P Shankley
Journal:  Br J Pharmacol       Date:  1985-11       Impact factor: 8.739

Review 5.  Cimetidine: a review of its pharmacological properties and therapeutic efficacy in peptic ulcer disease.

Authors:  R N Brogden; R C Heel; T M Speight; G S Avery
Journal:  Drugs       Date:  1978-02       Impact factor: 9.546

6.  Effects of SCH 32651 on resting and stimulated acid secretion in guinea-pig isolated fundic mucosa.

Authors:  A Barnett; P J Chiu; G Tetzloff
Journal:  Br J Pharmacol       Date:  1984-09       Impact factor: 8.739

7.  The effect of cimetidine on cyclic nucleotides in human gastric mucosa.

Authors:  P A Mooney; J M Walters; C F McCarthy; J M O'Donnell
Journal:  Br J Clin Pharmacol       Date:  1981-08       Impact factor: 4.335
  7 in total

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