| Literature DB >> 1330984 |
M Namavari1, A Bishop, N Satyamurthy, G Bida, J R Barrio.
Abstract
A protected 6-trimethylstannyl dopa derivative 6 has been synthesized for the first time as a precursor for the preparation of 6-[18F]fluoro-L-dopa. The tin derivative 6 readily reacted with electrophilic radiofluorinating agents such as [18F]F2 and [18F]AcOF. The [18F]fluoro intermediate 7 was easily hydrolyzed with HBr and the product 6-[18F]fluoro-L-dopa was isolated after HPLC purification in a maximum radiochemical yield of 25%, ready for human use. The various intermediates, the stannyl precursor 6 and the final product (after 18F decay) were all fully characterized by 1H, 13C, 19F and 119Sn NMR as well as high resolution mass spectroscopy.Entities:
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Year: 1992 PMID： 1330984 DOI： 10.1016/0883-2889(92)90217-3
Source DB: PubMed Journal: Int J Rad Appl Instrum A ISSN： 0883-2889