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Literature DB >> 1330879

Frequent polymorphism in the 13th exon of the adenomatous polyposis coli gene.

S Olschwang¹, P Laurent-Puig, B Thuille, G Thomas.

Abstract

We have studied the DNA from 170 individuals affected with familial adenomatous polyposis and from 20 uneffected individuals. Denaturing gradient gel electrophoresis of polymerase chain reaction amplified DNA from the adenomatous polyposis coli (APC) gene demonstrated three major patterns consistent with the existence of two different sequences in exon 13 of the gene in the human population. Direct sequencing of the amplified product from DNAs producing these three patterns confirmed the presence of a polymorphism in the coding region of the APC gene.

Entities: Disease Gene Species

Mesh：

Substances：
Oligonucleotide Probes

Year: 1992 PMID： 1330879 DOI： 10.1007/bf00210765

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

9 in total

1. Computational simulation of DNA melting and its application to denaturing gradient gel electrophoresis.

Authors: L S Lerman; K Silverstein
Journal: Methods Enzymol Date: 1987 Impact factor: 1.600

2. Screening guidelines and premorbid diagnosis of familial adenomatous polyposis using linkage.

Authors: G M Petersen; J Slack; Y Nakamura
Journal: Gastroenterology Date: 1991-06 Impact factor: 22.682

3. Identification of deletion mutations and three new genes at the familial polyposis locus.

Authors: G Joslyn; M Carlson; A Thliveris; H Albertsen; L Gelbert; W Samowitz; J Groden; J Stevens; L Spirio; M Robertson
Journal: Cell Date: 1991-08-09 Impact factor: 41.582

4. Localization of the gene for familial adenomatous polyposis on chromosome 5.

Authors: W F Bodmer; C J Bailey; J Bodmer; H J Bussey; A Ellis; P Gorman; F C Lucibello; V A Murday; S H Rider; P Scambler
Journal: Nature Date: 1987 Aug 13-19 Impact factor: 49.962

5. The value of screening and central registration of families with familial adenomatous polyposis. A study of 82 families in The Netherlands.

Authors: H F Vasen; G Griffioen; G J Offerhaus; F C Den Hartog Jager; I S Van Leeuwen-Cornelisse; P Meera Khan; C B Lamers; E A Van Slooten
Journal: Dis Colon Rectum Date: 1990-03 Impact factor: 4.585

1 in total

1. Germ-line mutations in the first 14 exons of the adenomatous polyposis coli (APC) gene.

Authors: S Olschwang; P Laurent-Puig; J Groden; R White; G Thomas
Journal: Am J Hum Genet Date: 1993-02 Impact factor: 11.025

1 in total

Frequent polymorphism in the 13th exon of the adenomatous polyposis coli gene.

1. Computational simulation of DNA melting and its application to denaturing gradient gel electrophoresis.

2. Screening guidelines and premorbid diagnosis of familial adenomatous polyposis using linkage.

3. Identification of deletion mutations and three new genes at the familial polyposis locus.

4. Localization of the gene for familial adenomatous polyposis on chromosome 5.

5. The value of screening and central registration of families with familial adenomatous polyposis. A study of 82 families in The Netherlands.

6. The gene for familial polyposis coli maps to the long arm of chromosome 5.

7. Identification and characterization of the familial adenomatous polyposis coli gene.

8. Identification of FAP locus genes from chromosome 5q21.

9. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients.

1. Germ-line mutations in the first 14 exons of the adenomatous polyposis coli (APC) gene.