Literature DB >> 1330680

Effect of perturbing diacylglycerol metabolism on cytosolic free Ca2+ oscillations induced in single hepatocytes.

A Sanchez-Bueno1, P H Cobbold.   

Abstract

Single rat hepatocytes microinjected with aequorin show free Ca oscillations when stimulated with Ca(2+)-mobilizing hormones. We show here that an inhibitor of diacylglycerol kinase (R 59 022) and an analogue of native diacylglycerol (diC8) inhibit free Ca oscillations induced by phenylephrine and vasopressin. These results agree with a negative feedback effect of protein kinase C on free Ca oscillations.

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Year:  1992        PMID： 1330680     DOI： 10.1016/0014-5793(92)81409-f

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  2 in total

1.  Suppression of agonist induced Ca2+ oscillations in cultured hepatocytes by nafenopin: possible involvement of protein kinase C.

Authors:  E Leibold; A Stampfl; L R Schwarz
Journal:  Arch Toxicol       Date:  1996       Impact factor: 5.153

2.  Agonist-specific behaviour of the intracellular Ca2+ response in rat hepatocytes.

Authors:  J Y Chatton; Y Cao; J W Stucki
Journal:  Biochem J       Date:  1997-12-01       Impact factor: 3.857
  2 in total

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