Literature DB >> 1330613

Cyclic AMP-dependent increase of steroidogenesis in brain cortical minces.

M L Barbaccia1, G Roscetti, M Trabucchi, C Ambrosio, M Massotti.   

Abstract

Rat brain cortical minces were incubated with forskolin and dibutyryl-cyclic AMP for 60 and 30 min, respectively. The concentrations of pregnenolone, progesterone and desoxycorticosterone in this preparation were significantly increased by both substances. The results indicate that, in brain tissue, steroidogenesis appears to be regulated by receptor transduction mechanisms that operate through adenylate cyclase.

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Year:  1992        PMID: 1330613     DOI: 10.1016/0014-2999(92)90495-p

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN: 0014-2999            Impact factor:   4.432


  2 in total

1.  Changes in neuroactive steroid concentrations after preterm delivery in the Guinea pig.

Authors:  Meredith A Kelleher; Jonathan J Hirst; Hannah K Palliser
Journal:  Reprod Sci       Date:  2013-04-12       Impact factor: 3.060

2.  Increased allopregnanolone levels in the fetal sheep brain following umbilical cord occlusion.

Authors:  Phuong N Nguyen; Edwin B Yan; Margie Castillo-Melendez; David W Walker; Jonathan J Hirst
Journal:  J Physiol       Date:  2004-08-26       Impact factor: 5.182

  2 in total

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