Literature DB >> 1330586

Carbon dioxide inhalation reduces the function of GABAA receptors in the rat brain.

E Sanna1, T Cuccheddu, M Serra, A Concas, G Biggio.   

Abstract

The effect of CO2 inhalation on the function of the GABA(A)-coupled chloride channel was evaluated in rat brain. This treatment decreased the capability of GABA to stimulate 36Cl- uptake and produced a significant increase of [35S]-TBPS ([35S]t-butylbicyclophosphorothionate) binding in the cerebral cortex, cerebellum and hippocampus. These results demonstrate that a brief exposure of rats to CO2 inhalation reduces the function of the GABA(A)-ionophore receptor complex in rat brain.

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Year:  1992        PMID： 1330586     DOI： 10.1016/0014-2999(92)90447-c

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  9 in total

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  9 in total

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