| Literature DB >> 1330307 |
R Astarloa1, M A Mena, V Sánchez, L de la Vega, J G de Yébenes.
Abstract
In this study, the effects of a diet rich in insoluble fiber (DRIF) on motor disability and the peripheral pharmacokinetics of orally administered L-dopa in Parkinsonian patients with marked constipation are analyzed. We found a useful effect of a DRIF on plasma L-dopa concentration and motor function. The greatest effect on the plasma L-dopa levels was found early (at 30 and 60 min) after oral administration. There was a relationship between the improvement of constipation and the higher bioavailability of L-dopa. DRIF can be a coadjuvant treatment in patients with Parkinson's disease.Entities:
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Year: 1992 PMID： 1330307 DOI： 10.1097/00002826-199210000-00004
Source DB: PubMed Journal: Clin Neuropharmacol ISSN： 0362-5664 Impact factor: 1.592