| Literature DB >> 1329640 |
A Weinberg1, B J Bate, H B Masters, S A Schneider, J C Clark, C G Wren, J A Allaman, M J Levin.
Abstract
Penciclovir (PCV) and acyclovir are acyclic guanine analogs which inhibit herpes simplex virus (HSV) DNA polymerase. Their 50% infective doses were 0.5 to 0.8 microgram/ml for clinical isolates of HSV-1 and 1.3 to 2.2 micrograms/ml for HSV-2. Furthermore, HSV-infected cultures receiving 2-h pulses of PCV had 2- to 50-fold less HSV than acyclovir-treated cultures, consistent with the prolonged intracellular half-life of PCV triphosphate.Entities:
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Year: 1992 PMID： 1329640 PMCID： PMC192432 DOI： 10.1128/AAC.36.9.2037
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191