| Literature DB >> 1328888 |
A Hemmati-Brivanlou1, D A Melton.
Abstract
Activins can induce mesoderm in embryonic explants and have been proposed as the natural inducer in Xenopus. A mutant activin receptor that inhibits activin signalling is used to show that activin is required for the induction of mesoderm in vivo and the patterning of the embryonic body plan. Blocking the activin signal transduction pathway also reveals autonomous induction of a neural marker and unmasks a relationship between activin and fibroblast growth factor.Entities:
Mesh：
Substances：
Year: 1992 PMID： 1328888 DOI： 10.1038/359609a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962