| Literature DB >> 1328496 |
A Adams1, M Mohrman, A G Johnson, A Morin, E Deschamps de Paillette.
Abstract
Treatment of BALB/c mice with poly(A):poly(U) 18 h prior to infection with a lethal dose of murine cytomegalovirus (MCMV) increased survival. In parallel with increased survival, a 10- to 100-fold reduction of plaque-forming MCMV was found in the liver and spleen of mice 4 days post-infection with a sublethal dose of MCMV. Poly(A):poly(U) did not significantly increase natural killer cell activity or prolong the duration of elevated cytotoxic activity in infected animals. The possible role of interferon in the poly(A):poly(U)-induced protection of BALB/c mice is discussed.Entities:
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Year: 1992 PMID： 1328496 DOI： 10.1099/0022-1317-73-9-2409
Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891