| Literature DB >> 1328411 |
L K Alexander1, J D Small, S Edwards, R S Baric.
Abstract
A rabbit model for coronavirus-induced dilated cardiomyopathy is described. Acute rabbit coronavirus infection results in virus-induced myocarditis and congestive heart failure. Of the survivors of rabbit coronavirus infection, 41% had increased heart weight and heart weight-to-body weight ratios, biventricular dilation, myocyte hypertrophy, myocardial fibrosis, and myocarditis consistent with the development of dilated cardiomyopathy. These changes were also seen in the remaining 59% of the survivors, except that the degree of myocyte hypertrophy was reduced and only right ventricular dilation was present. In most survivors, myocarditis was usually mild (1-5 foci/transverse section), but in some cases it was severe (> 20 foci/transverse section). Interstitial and replacement fibrosis was more pronounced in the papillary muscles. These data suggest that rabbit coronavirus infection may progress to dilated cardiomyopathy.Entities:
Mesh：
Year: 1992 PMID： 1328411 PMCID： PMC7109931 DOI： 10.1093/infdis/166.5.978
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226