Literature DB >> 1328122

Preparation and characterization of a murine monoclonal antibody (MDR3M) reactive with mdr3 gene product.

I Sugawara1, A Hirata, K Ueda, S Itoyama.   

Abstract

A murine monoclonal antibody (MDR3M) (isotype: IgM) reactive with mdr3 gene product was generated by immunizing mice with mdr3-specific peptide (H2N-12WRPTSAEGDFELGISSKQKRKKTKTVKMI41G-COOH) and hybridizing the primed mouse splenic B cells with X63-Ag8,6.5.3 mouse plasmacytoma cells. MDR3M did not cross-react with mdr1 gene product. This monoclonal antibody may be useful for analyzing the role of mdr3 gene product in cells and tissues.

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Year:  1992        PMID： 1328122      PMCID： PMC5918957          DOI： 10.1111/j.1349-7006.1992.tb01982.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  21 in total

1.  Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells.

Authors:  M Raymond; E Rose; D E Housman; P Gros
Journal:  Mol Cell Biol       Date:  1990-04       Impact factor: 4.272

2.  Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells. Evidence that distinct P-glycoprotein precursors are encoded by unique mdr genes.

Authors:  S I Hsu; L Lothstein; S B Horwitz
Journal:  J Biol Chem       Date:  1989-07-15       Impact factor: 5.157

3.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors:  H Towbin; T Staehelin; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

Review 4.  Multiple-drug resistance in human cancer.

Authors:  I Pastan; M Gottesman
Journal:  N Engl J Med       Date:  1987-05-28       Impact factor: 91.245

5.  Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

Authors:  W T Beck; T J Mueller; L R Tanzer
Journal:  Cancer Res       Date:  1979-06       Impact factor: 12.701

6.  Sequence of mdr3 cDNA encoding a human P-glycoprotein.

Authors:  A M van der Bliek; P M Kooiman; C Schneider; P Borst
Journal:  Gene       Date:  1988-11-30       Impact factor: 3.688

7.  Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies.

Authors:  E Georges; G Bradley; J Gariepy; V Ling
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

8.  Expression of the mdr3 gene in prolymphocytic leukemia: association with cyclosporin-A-induced increase in drug accumulation.

Authors:  K Nooter; P Sonneveld; A Janssen; R Oostrum; T Boersma; H Herweijer; D Valerio; A Hagemeijer; F Baas
Journal:  Int J Cancer       Date:  1990-04-15       Impact factor: 7.396

9.  Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine.

Authors:  H Herweijer; P Sonneveld; F Baas; K Nooter
Journal:  J Natl Cancer Inst       Date:  1990-07-04       Impact factor: 13.506

10.  Cellular and tissue distribution of MRK20 murine monoclonal antibody-defined 85-kDa protein in adriamycin-resistant cancer cell lines.

Authors:  I Sugawara; E Ohkochi; H Hamada; T Tsuruo; S Mori
Journal:  Jpn J Cancer Res       Date:  1988-10
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