Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Comparative studies of neoplastic response to a single dose of nitroso compounds. 5. The effect of dimethylnitrosamine in Swiss, ASW/SN and A-strain mice.

Literature DB >> 132789

Comparative studies of neoplastic response to a single dose of nitroso compounds. 5. The effect of dimethylnitrosamine in Swiss, ASW/SN and A-strain mice.

Y I Cardesa, K Patil, J Althoff, P Pour.

Abstract

The tumorigenic effect of dimethylnitrosamine given once at 5 different dose levels was compared in adult Swiss, ASW/SN and A-strain mice. Considering the overall tumour incidence, at the highest dose level an increase was found in Swiss and ASW/SN mice, but not in A-strain animals. However, the effect of treatment was unequivocal for lung neoplasms. The rate of carcinomas rose significantly in all 3 strains, although a clear dose response-relationship could be established only in Swiss and ASW/SN mice. A dose-dependent effect for adenomas was found solely in Swiss mice.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1976 PMID： 132789 DOI： 10.1007/bf00284004

Source DB: PubMed Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol ISSN： 0084-5353

Keyword Cloud
References

13 in total

1. INDUCTION OF MALIGNANT TUMORS IN VARIOUS STRAINS OF MICE BY ORAL ADMINISTRATION OF N-NITROSODIMETHYLAMINE AND N-NITROSODIETHYLAMINE.

Authors: S TAKAYAMA; K OOTA
Journal: Gan Date: 1965-04

Comparative studies of neoplastic response to a single dose of nitroso compounds. 5. The effect of dimethylnitrosamine in Swiss, ASW/SN and A-strain mice.

1. INDUCTION OF MALIGNANT TUMORS IN VARIOUS STRAINS OF MICE BY ORAL ADMINISTRATION OF N-NITROSODIMETHYLAMINE AND N-NITROSODIETHYLAMINE.

2. The syncarcinogenic effect of methylcholanthrene and dimethylnitrosamine in Swiss mice.

3. Carcinogenesis in AKR mice injected at birth with benzo(a)pyrene and dimethylnitrosamine.

4. Vascular tumors in female mice after intraperitoneal injection of dimethylnitrosamine.

Review 5. A critical review of experiments in chemical carcinogensis using newborn animals.

6. Pulmonary and hepatic oncogenesis during treatment of male RF mice with dimethyl-nitrosamine.

7. A study of nitrosamines and S-carboxyl derivatives of cysteine as lung carcinogens in adult SWR mice.

8. Effect of cumulative dose and dose rate on dimethylnitrosamine oncogenesis in RF mice.

9. Carcinogenicity of dimethylnitrosamine in Swiss mice.

10. [Urethan carcinogenesis in newborn, suckling, and adult mice of C57BL, C3H, BC3F1, C3Hf, and SWR strains].