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Literature DB >> 132785

[On the cytosic action of N-methyl-N-beta-chloraethyl-hydrazine and its benzaldehydhydrazone (author's transl)].

Abstract

N-Methyl-N-beta-chloroethyl-hydrazine and its benzaldehydhydrazone are two new cytostatic methylhydrazines. Administered intraperitoneally, they are more effective in inhibiting the ascites tumor growth (Ehrlich's carcinoma in mice and Yoshida sarcoma in rats) than procarbazine in vitro as well as in vivo. The intraperitoneal administration of hydrazone shows a minor effect on the solid tumor. This may be explained by a different pharmacocinetical behaviour. Hydrazone is less toxic than procarbazine.

Entities: Chemical Disease Species

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Year: 1976 PMID： 132785 DOI： 10.1007/bf00284000

Source DB: PubMed Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol ISSN： 0084-5353

9 in total

7 in total

6. The influence of N-methyl-N-beta-chloroethyl hydrazines on the mitotic index of Ehrlich ascites tumor cells and the leukopoiesis of the mouse.

Authors: R Braun; G Wolf
Journal: Experientia Date: 1977-01-15

7. Mutagenic activity of cytostatic methyl hydrazones with different strains of Salmonella typhimurium.

Authors: D Gericke; R Braun; W Dittmar
Journal: Arch Toxicol Date: 1979-07-11 Impact factor: 5.153

7 in total

[On the cytosic action of N-methyl-N-beta-chloraethyl-hydrazine and its benzaldehydhydrazone (author's transl)].

1. THE TUMOR-INHIBITORY EFFECTS OF THE METHYLHYDRAZINE DERIVATIVE RO 4-6467/1 (NSC-77213).

2. [STUDIES ON THE CYTOSTATIC MECHANISM OF ACTION OF METHYLHYDRAZINE].

3. [ON THE METABOLISM OF A CYTOSTATIC METHYLHYDRAZINE DERIVATIVE (NATULAN)].

4. Methylhydrazine derivatives, a new class of cytotoxic agents.

5. Tumour inhibitory effects of a new class of cytotoxic agents: methylhydrazine derivatives.

6. [beta-Chloro- and beta-mesylethyl hydrazines].

7. Studies of the mode of action of N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide.

8. [N,N-dimethylhydrazinium salts as new growth regulators].

9. [Studies on the mechanism of cytostatic action of methylhydrazine, II].

1. [Anti-leukemia effect of N'-methyl N'-beta-chlorethylhydrazones].

2. [The immunosuppressive effects of N-methyl-N'-beta-chlorethylhydrazones].

3. The influence of cytostatic methyl hydrazones on the intracellular pH and viability of tumor cells.

4. [The anti-leukemic and immunosuppressive effect of methylhydrazones].

5. The influence of a new antitumor agent on hemopoietic colony forming cells.

6. The influence of N-methyl-N-beta-chloroethyl hydrazines on the mitotic index of Ehrlich ascites tumor cells and the leukopoiesis of the mouse.

7. Mutagenic activity of cytostatic methyl hydrazones with different strains of Salmonella typhimurium.