OBJECTIVE: To estimate the risk of infection with HIV (HIV 1 or HIV 2, or both) from transfusion of a screened unit of blood in a high prevalence area in west Africa. DESIGN: Retrospective cohort study for January-July 1991. SETTING: National Blood Transfusion Centre, Abidjan, Côte d'Ivoire. SUBJECTS: Repeat donors (5831 units of blood) and first time donors (5076 units) in the first five months of 1991. MAIN OUTCOME MEASURES: Prevalence and estimated incidence of HIV infection in repeat and first time donors; estimated rate of potentially infected, HIV antibody negative units; and rate of (false negative) potentially infected units assuming a laboratory test sensitivity of 99%. RESULTS: Overall HIV prevalence was 11.0% in first time donors and 2.1% in repeat donors. In the first seven months of 1991, 29 HIV antibody positive (27 HIV 1, 1 HIV 2, 1 dually reactive) donors with a seronegative unit of blood earlier in the year were identified; 26 had donated blood eight weeks or less before their estimated dates of seroconversion and may have been infectious (minimum rate 26/5831 (4.5/1000 potentially infected units)). Estimated incidence of infection in repeat donors was 1.2-2.5%. Laboratory test insensitivity would result in an estimated 1.1/1000 false negative units from first time donors and 0.2/1000 units from regular donors. The overall rate of potentially infected units (all donors, seroconversions, and errors) was estimated at 5.4-10.6/1000. CONCLUSIONS: The risk of HIV infection from a single unit of blood remains substantial (5.4-10.6/1000 units). To prevent infection from blood transfusion in areas of high incidence and prevalence of HIV all but absolutely essential transfusions should be avoided, and donors with low incidence of HIV infection should be selected.
OBJECTIVE: To estimate the risk of infection with HIV (HIV 1 or HIV 2, or both) from transfusion of a screened unit of blood in a high prevalence area in west Africa. DESIGN: Retrospective cohort study for January-July 1991. SETTING: National Blood Transfusion Centre, Abidjan, Côte d'Ivoire. SUBJECTS: Repeat donors (5831 units of blood) and first time donors (5076 units) in the first five months of 1991. MAIN OUTCOME MEASURES: Prevalence and estimated incidence of HIV infection in repeat and first time donors; estimated rate of potentially infected, HIV antibody negative units; and rate of (false negative) potentially infected units assuming a laboratory test sensitivity of 99%. RESULTS: Overall HIV prevalence was 11.0% in first time donors and 2.1% in repeat donors. In the first seven months of 1991, 29 HIV antibody positive (27 HIV 1, 1 HIV 2, 1 dually reactive) donors with a seronegative unit of blood earlier in the year were identified; 26 had donated blood eight weeks or less before their estimated dates of seroconversion and may have been infectious (minimum rate 26/5831 (4.5/1000 potentially infected units)). Estimated incidence of infection in repeat donors was 1.2-2.5%. Laboratory test insensitivity would result in an estimated 1.1/1000 false negative units from first time donors and 0.2/1000 units from regular donors. The overall rate of potentially infected units (all donors, seroconversions, and errors) was estimated at 5.4-10.6/1000. CONCLUSIONS: The risk of HIV infection from a single unit of blood remains substantial (5.4-10.6/1000 units). To prevent infection from blood transfusion in areas of high incidence and prevalence of HIV all but absolutely essential transfusions should be avoided, and donors with low incidence of HIV infection should be selected.
Entities:
Keywords:
Africa; Africa South Of The Sahara; Antibodies--analysis; Biology; Blood Supply; Cohort Analysis; Developing Countries; Diseases; Equipment And Supplies; Estimation Technics; Examinations And Diagnoses; French Speaking Africa; Hiv Infections--transmission; Immunity; Immunologic Factors; Incidence; Ivory Coast; Measurement; Physiology; Prevalence; Research Methodology; Retrospective Studies; Risk Factors; Screening; Studies; Viral Diseases; Western Africa
Authors: K M De Cock; J C Niland; H P Lu; A Rahimian; V Edwards; K Shriver; S Govindarajan; A G Redeker Journal: Am J Epidemiol Date: 1988-06 Impact factor: 4.897
Authors: G W Rutherford; A R Lifson; N A Hessol; W W Darrow; P M O'Malley; S P Buchbinder; J L Barnhart; T W Bodecker; L Cannon; L S Doll Journal: BMJ Date: 1990-11-24
Authors: K M De Cock; A Porter; J Kouadio; M Maran; E Gnaore; G Adjorlolo; M F Lafontaine; G Bretton; G M Damet; K Odehouri Journal: AIDS Date: 1990-09 Impact factor: 4.177
Authors: H J Alter; J S Epstein; S G Swenson; M J VanRaden; J W Ward; R A Kaslow; J E Menitove; H G Klein; S G Sandler; M H Sayers Journal: N Engl J Med Date: 1990-11-08 Impact factor: 91.245
Authors: B N'Galy; R W Ryder; K Bila; K Mwandagalirwa; R L Colebunders; H Francis; J M Mann; T C Quinn Journal: N Engl J Med Date: 1988-10-27 Impact factor: 91.245
Authors: J W Ward; S D Holmberg; J R Allen; D L Cohn; S E Critchley; S H Kleinman; B A Lenes; O Ravenholt; J R Davis; M G Quinn Journal: N Engl J Med Date: 1988-02-25 Impact factor: 91.245