| Literature DB >> 1327175 |
K Sagar1, J M Fernandez Alvarez, C Hua, M R Smyth, R Munden.
Abstract
A voltammetric study of the oxidation of sumatriptan succinate (1:1) has been carried out at the glassy carbon electrode. This compound exhibited a single wave in Britton-Robinson buffer solutions of pH 2-11, with a maximum current at pH 5.0. The mechanism of oxidation was shown to be due to oxidation of the N-H group in the indole ring. Based on this study, a simple, rapid and sensitive voltammetric method was developed for the determination of the drug in a tablet dosage form.Entities:
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Year: 1992 PMID： 1327175 DOI： 10.1016/0731-7085(92)80005-8
Source DB: PubMed Journal: J Pharm Biomed Anal ISSN： 0731-7085 Impact factor: 3.935