Literature DB >> 1326951

The endothelin-A receptor subtype transduces the effects of the endothelins in the anterior pituitary gland.

W K Samson1.   

Abstract

All members of the mammalian endothelin family of peptides exert significant effects on prolactin and luteinizing hormone release from dispersed anterior pituitary cells in vitro. The rank order of potency for the prolactin inhibiting effects of the endothelins is ET-1 = ET-2 much less than ET-3. This suggests an involvement of the ET-A receptor subtype. The selective ET-A receptor antagonist BQ-123 antagonized the effects of the ETs in a competitive fashion with pA2 values of 6.1 (ET-1), 5.7 (ET-2) and 6.4 (ET-3), when added simultaneously with the ETs. This suggests the involvement of the ET-A receptor subtype in the actions of the ETs within the anterior pituitary gland.

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Year:  1992        PMID： 1326951     DOI： 10.1016/0006-291x(92)91235-i

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  7 in total

1.  Autocrine regulation of prolactin secretion by endothelins throughout the estrous cycle.

Authors:  Béla Kanyicska; Michael T Sellix; Marc E Freeman
Journal:  Endocrine       Date:  2003 Feb-Mar       Impact factor: 3.633

Review 2.  Ion channels and signaling in the pituitary gland.

Authors:  Stanko S Stojilkovic; Joël Tabak; Richard Bertram
Journal:  Endocr Rev       Date:  2010-07-21       Impact factor: 19.871

3.  The endothelin ETA receptor exists in the caudal solitary tract nucleus of the rat brain.

Authors:  S Shibata; M Niwa; A Himeno; N G Gana; K Shigematsu; M Matsumoto; K Yamashita; K Sumikawa; K Taniyama
Journal:  Cell Mol Neurobiol       Date:  1997-02       Impact factor: 5.046

4.  Dependence of prolactin release on coupling between Ca(2+) mobilization and voltage-gated Ca(2+) influx pathways in rat lactotrophs.

Authors:  Melanija Tomić; Silvna A Andric; Stanko S Stojilkovic
Journal:  Endocrine       Date:  2003 Feb-Mar       Impact factor: 3.633

5.  Expression of Ca(2+)-mobilizing endothelin(A) receptors and their role in the control of Ca(2+) influx and growth hormone secretion in pituitary somatotrophs.

Authors:  M Tomić; D Zivadinovic; F Van Goor; D Yuan; T Koshimizu; S S Stojilkovic
Journal:  J Neurosci       Date:  1999-09-15       Impact factor: 6.167

6.  Endothelin receptors in rat pituitary gland.

Authors:  S Shibata; A Himeno; K Shigematsu; K Tsutsumi; Y Sakurai-Yamashita; K Yamashita
Journal:  Cell Mol Neurobiol       Date:  1997-02       Impact factor: 5.046

Review 7.  Multiple roles of Gi/o protein-coupled receptors in control of action potential secretion coupling in pituitary lactotrophs.

Authors:  Stanko S Stojilkovic; Takayo Murano; Arturo E Gonzalez-Iglesias; Silvana A Andric; Marko A Popovic; Fredrick Van Goor; Melanija Tomić
Journal:  Ann N Y Acad Sci       Date:  2009-01       Impact factor: 5.691
  7 in total

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