Literature DB >> 1326585

A ganciclovir-resistant clinical isolate of human cytomegalovirus exhibiting cross-resistance to other DNA polymerase inhibitors.

W A Tatarowicz1, N S Lurain, K D Thompson.   

Abstract

Clinical isolates of human cytomegalovirus (HCMV) were screened for susceptibility to ganciclovir by plaque-reduction assay and in situ ELISA. A pretreatment isolate of HCMV obtained from the bronchial brushing of a heart transplant recipient contained both ganciclovir-susceptible and -resistant virus. Ganciclovir-susceptible (P8) and -resistant (D16) strains were further isolated by plaque purification. Both strains phosphorylated ganciclovir at levels similar to the ganciclovir-susceptible strain AD169. D16 was also resistant to phosphonoformic acid and to (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and cytosine. These data suggest that the resistance of D16 to these drugs results from a mutation in the viral DNA polymerase gene.

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Year:  1992        PMID： 1326585     DOI： 10.1093/infdis/166.4.904

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  18 in total

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Review 3.  New strategies for prevention and therapy of cytomegalovirus infection and disease in solid-organ transplant recipients.

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6.  Rapid screening for resistance to ganciclovir and foscarnet of primary isolates of human cytomegalovirus from culture-positive blood samples.

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Review 7.  "The end of innocence" revisited: resistance of herpesviruses to antiviral drugs.

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8.  Human cytomegalovirus UL97 kinase confers ganciclovir susceptibility to recombinant vaccinia virus.

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9.  Mutation in the UL97 open reading frame of human cytomegalovirus strains resistant to ganciclovir.

Authors:  N S Lurain; L E Spafford; K D Thompson
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10.  Inhibition of human cytomegalovirus in culture by alkenyl guanine analogs of the thiazolo[4,5-d]pyrimidine ring system.

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