| Literature DB >> 1326436 |
S Simonet1, E Bonhomme, M Laubie, C Thurieau, J L Fauchère, T J Verbeuren.
Abstract
The effects of thrombin and a peptide mimicking the amino terminus of its receptor, Res (42-55), on vascular reactivity were compared in isolated canine blood vessels. In saphenous veins contracted with endothelin-1, both thrombin and Res (42-55) caused relaxation in rings with endothelium and contraction in rings without endothelium. In coronary arteries, thrombin caused similar responses while Res (42-55) only caused contraction. These data suggest that different thrombin receptors are present on venous and arterial endothelial cells.Entities:
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Year: 1992 PMID： 1326436 DOI： 10.1016/0014-2999(92)90222-p
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432