| Literature DB >> 1325796 |
R Yamada1, T Suzuki, M Hashimoto, Y Eto, K Shiokawa, M Muramatsu.
Abstract
A human promyelocytic cell line, HL-60, treated with activin/EDF was found to differentiate into monocyte/macrophage-like cells. This was shown not only by morphology but by the loss of myeloperoxidase granules and the appearance of nonspecific esterase. Dose-dependent inhibition of the differentiation by follistatin, an activin-binding protein, confirmed that it was indeed caused by activin. Thus, activin/EDF exerts its effect on hematopoietic cells not only on erythroid differentiation but also on at least a part of myeloid cell differentiation.Entities:
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Year: 1992 PMID： 1325796 DOI： 10.1016/s0006-291x(05)81461-5
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575