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Literature DB >> 1325734

The genetics of Wilms' tumor.

D A Haber¹, D E Housman.

Abstract

Entities: Disease

Mesh：

Year: 1992 PMID： 1325734 DOI： 10.1016/s0065-230x(08)60302-4

Source DB: PubMed Journal: Adv Cancer Res ISSN： 0065-230X Impact factor: 6.242

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12 in total

1. Altered expression of the WT1 wilms tumor suppressor gene in human breast cancer.

Authors: G B Silberstein; K Van Horn; P Strickland; C T Roberts; C W Daniel
Journal: Proc Natl Acad Sci U S A Date: 1997-07-22 Impact factor: 11.205

2. A dominant mutation in the Wilms tumor gene WT1 cooperates with the viral oncogene E1A in transformation of primary kidney cells.

Authors: D A Haber; H T Timmers; J Pelletier; P A Sharp; D E Housman
Journal: Proc Natl Acad Sci U S A Date: 1992-07-01 Impact factor: 11.205

3. Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70.

Authors: S Maheswaran; C Englert; G Zheng; S B Lee; J Wong; D P Harkin; J Bean; R Ezzell; A J Garvin; R T McCluskey; J A DeCaprio; D A Haber
Journal: Genes Dev Date: 1998-04-15 Impact factor: 11.361

4. A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1.

Authors: R W Johnstone; R H See; S F Sells; J Wang; S Muthukkumar; C Englert; D A Haber; J D Licht; S P Sugrue; T Roberts; V M Rangnekar; Y Shi
Journal: Mol Cell Biol Date: 1996-12 Impact factor: 4.272

The genetics of Wilms' tumor.

1. Altered expression of the WT1 wilms tumor suppressor gene in human breast cancer.

2. A dominant mutation in the Wilms tumor gene WT1 cooperates with the viral oncogene E1A in transformation of primary kidney cells.

3. Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70.

4. A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1.

5. Truncated WT1 mutants alter the subnuclear localization of the wild-type protein.

6. Physical and functional interaction between WT1 and p53 proteins.

Review 7. Tumor suppressor genes in molecular medicine.

8. Polycystic kidney disease as a result of loss of the tuberous sclerosis 2 tumor suppressor gene during development.

Review 9. Regulation of gene expression by WT1 in development and tumorigenesis.

10. Sequence and structural requirements for high-affinity DNA binding by the WT1 gene product.