Literature DB >> 1325368

Serotonin enhances the beta-adrenergic response in rat brain cortical slices.

D Morin1, R Sapena, R Zini, J P Tillement.   

Abstract

Serotonin increased the isoproterenol-induced cyclic AMP accumulation in rat brain cortical slices but did not itself stimulate the production of cyclic AMP in this area. This effect appeared to be inhibited by the 5-HT2 receptor antagonist, ritanserin. This potentiation was not observed in the hippocampus. These data reinforce the hypothesis of a coupling between the noradrenergic and serotonergic systems, which may be involved in the mechanism of action of antidepressant drugs.

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Year:  1992        PMID： 1325368     DOI： 10.1016/0922-4106(92)90029-u

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

1.  pCREB in the neonate rat olfactory bulb is selectively and transiently increased by odor preference-conditioned training.

Authors:  J H McLean; C W Harley; A Darby-King; Q Yuan
Journal:  Learn Mem       Date:  1999 Nov-Dec       Impact factor: 2.460

2.  Isoproterenol increases CREB phosphorylation and olfactory nerve-evoked potentials in normal and 5-HT-depleted olfactory bulbs in rat pups only at doses that produce odor preference learning.

Authors:  Q Yuan; C W Harley; J C Bruce; A Darby-King; J H McLean
Journal:  Learn Mem       Date:  2000 Nov-Dec       Impact factor: 2.460

3.  Up-regulation of beta 1-adrenergic receptors in rat brain after chronic citalopram and fluoxetine treatments.

Authors:  E P Pälvimäki; A Laakso; M Kuoppamäki; E Syvälahti; J Hietala
Journal:  Psychopharmacology (Berl)       Date:  1994-08       Impact factor: 4.530

4.  Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: effects on serotonin systems in adolescence and adulthood.

Authors:  Theodore A Slotkin; Ian T Ryde; Edward D Levin; Frederic J Seidler
Journal:  Brain Res Bull       Date:  2007-11-12       Impact factor: 4.077

5.  Mitral cell beta1 and 5-HT2A receptor colocalization and cAMP coregulation: a new model of norepinephrine-induced learning in the olfactory bulb.

Authors:  Qi Yuan; Carolyn W Harley; John H McLean
Journal:  Learn Mem       Date:  2003 Jan-Feb       Impact factor: 2.460

6.  Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibition.

Authors:  Theodore A Slotkin; Charlotte A Tate; Ian T Ryde; Edward D Levin; Frederic J Seidler
Journal:  Environ Health Perspect       Date:  2006-10       Impact factor: 9.031

7.  Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periods.

Authors:  Justin E Aldridge; Frederic J Seidler; Armando Meyer; Indira Thillai; Theodore A Slotkin
Journal:  Environ Health Perspect       Date:  2003-11       Impact factor: 9.031

8.  Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling.

Authors:  Justin E Aldridge; Frederic J Seidler; Theodore A Slotkin
Journal:  Environ Health Perspect       Date:  2004-02       Impact factor: 9.031
  8 in total

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