Literature DB >> 1324691

Regulation of TCR alpha and beta gene allelic exclusion during T-cell development.

M Malissen1, J Trucy, E Jouvin-Marche, P A Cazenave, R Scollay, B Malissen.   

Abstract

Early in their development, most T cells become committed to the expression of one, and only one, TCR alpha beta combination. How do T cells achieve this TCR allelic exclusion? This article discusses the configuration and expression of TCR alpha and beta genes in mature T-cell lines and TCR alpha beta transgenic mice, and proposes three nonexclusive models to account for the significant occurrence of T cells with two productive alpha gene rearrangements.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1324691     DOI： 10.1016/0167-5699(92)90044-8

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  77 in total

1.  Mechanisms that direct ordered assembly of T cell receptor beta locus V, D, and J gene segments.

Authors:  B P Sleckman; C H Bassing; M M Hughes; A Okada; M D'Auteuil; T D Wehrly; B B Woodman; L Davidson; J Chen; F W Alt
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-05       Impact factor: 11.205

Review 2.  Receptor selection in B and T lymphocytes.

Authors:  D Nemazee
Journal:  Annu Rev Immunol       Date:  2000       Impact factor: 28.527

3.  The tight interallelic positional coincidence that distinguishes T-cell receptor Jalpha usage does not result from homologous chromosomal pairing during ValphaJalpha rearrangement.

Authors:  F Davodeau; M Difilippantonio; E Roldan; M Malissen; J L Casanova; C Couedel; J F Morcet; M Merkenschlager; A Nussenzweig; M Bonneville; B Malissen
Journal:  EMBO J       Date:  2001-09-03       Impact factor: 11.598

4.  Random monoallelic expression of three genes clustered within 60 kb of mouse t complex genomic DNA.

Authors:  Y Sano; T Shimada; H Nakashima; R H Nicholson; J F Eliason; T A Kocarek; M S Ko
Journal:  Genome Res       Date:  2001-11       Impact factor: 9.043

5.  Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice.

Authors:  M Baker; J Gamble; R Tooze; D Higgins; F T Yang; P C O'Brien; N Coleman; S Pingel; M Turner; D R Alexander
Journal:  EMBO J       Date:  2000-09-01       Impact factor: 11.598

6.  T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes.

Authors:  Craig H Bassing; Robert E Tillman; Barbara B Woodman; David Canty; Robert J Monroe; Barry P Sleckman; Frederick W Alt
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-25       Impact factor: 11.205

7.  BALB/c alleles at modifier loci increase the severity of the maternal effect of the "DDK syndrome".

Authors:  S Le Bras; M Cohen-Tannoudji; C Kress; S Vandormael-Pournin; C Babinet; P Baldacci
Journal:  Genetics       Date:  2000-02       Impact factor: 4.562

8.  Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation.

Authors:  Eri Ishikawa; Yasunobu Miyake; Hiromitsu Hara; Takashi Saito; Sho Yamasaki
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-28       Impact factor: 11.205

9.  Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen.

Authors:  T Zal; A Volkmann; B Stockinger
Journal:  J Exp Med       Date:  1994-12-01       Impact factor: 14.307

10.  Rapid and selective expansion of nonclonotypic T cells in regulatory T cell-deficient, foreign antigen-specific TCR-transgenic scurfy mice: antigen-dependent expansion and TCR analysis.

Authors:  Rahul Sharma; Angela Chiao-Ying Ju; John T Kung; Shu Man Fu; Shyr-Te Ju
Journal:  J Immunol       Date:  2008-11-15       Impact factor: 5.422
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.