Literature DB >> 1324194

The angiotensin AT2 receptor modulates T-type calcium current in non-differentiated NG108-15 cells.

B Buisson1, S P Bottari, M de Gasparo, N Gallo-Payet, M D Payet.   

Abstract

We report here that angiotensin II (AII) and the AT2 receptor-selective ligand, CGP 42112, modulate the T-type calcium current in non-differentiated NG108-15 cells, which express only AT2 receptors. Both peptides decrease the T-type calcium current at membrane potentials above -40 mV and shift the current-voltage curve at lower potentials with maximal effect between 5 and 10 min after application. These data describe a new cellular response to AII and suggest that the AT2 receptor mediates certain neurophysiological actions of this hormone.

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Year:  1992        PMID： 1324194     DOI： 10.1016/0014-5793(92)81086-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  18 in total

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