OBJECTIVE: This study was undertaken to determine which part of ROI generation is reduced in the neutrophils from patients with NIDDM. RESEARCH DESIGN AND METHODS: Superoxide anion (O2-) production, LDCL activity in response to opsonized zymosan, and MPO activity were measured in leukocytes of poorly controlled NIDDM patients (FBG greater than 8.89 mM, HbA1 greater than 10%). RESULTS: In diabetic subjects, both O2- production and LDCL activity assessed with initial slope gradient and peak value were significantly reduced. MPO activity was also decreased in diabetic subjects, and there was a significant correlation between HbA1 levels and MPO activity of diabetic subjects. CONCLUSIONS: This study demonstrated that every step in leukocyte ROI generation should be reduced in the leukocytes from poorly controlled diabetic patients.
OBJECTIVE: This study was undertaken to determine which part of ROI generation is reduced in the neutrophils from patients with NIDDM. RESEARCH DESIGN AND METHODS: Superoxide anion (O2-) production, LDCL activity in response to opsonized zymosan, and MPO activity were measured in leukocytes of poorly controlled NIDDMpatients (FBG greater than 8.89 mM, HbA1 greater than 10%). RESULTS: In diabetic subjects, both O2- production and LDCL activity assessed with initial slope gradient and peak value were significantly reduced. MPO activity was also decreased in diabetic subjects, and there was a significant correlation between HbA1 levels and MPO activity of diabetic subjects. CONCLUSIONS: This study demonstrated that every step in leukocyte ROI generation should be reduced in the leukocytes from poorly controlled diabeticpatients.
Authors: Wenbo Zhi; Ashok Sharma; Sharad Purohit; Eric Miller; Bruce Bode; Stephen W Anderson; John Chip Reed; R Dennis Steed; Leigh Steed; Diane Hopkins; Jin-Xiong She Journal: Mol Cell Proteomics Date: 2011-09-06 Impact factor: 5.911
Authors: Mohammad Ali; Shahana Jasmin; Mohammad Fariduddin; Sheikh M K Alam; M I Arslan; Subrata K Biswas Journal: Mol Biol Rep Date: 2018-07-28 Impact factor: 2.316
Authors: Diana C Peniche-Palma; Bertha A Carrillo-Avila; Eduardo A Sauri-Esquivel; Karla Acosta-Viana; Vicente Esparza-Villalpando; Amaury Pozos-Guillen; Marcela Hernandez-Rios; Victor M Martinez-Aguilar Journal: Biomed Res Int Date: 2019-07-02 Impact factor: 3.411