Literature DB >> 1324044

A murine leukemia virus derived retroviral vector with a rat VL30 packaging psi sequence.

C Torrent1, P Wang, J L Darlix.   

Abstract

A rat VL30 packaging Psi sequence of 168 nucleotides has been characterized. It bears little or no homology to the Murine Leukemia Virus (MLV) Psi sequence, is much smaller in size and at least as efficient for packaging. The use of this small VL30 Psi sequence in MLV derived retroviral vectors should render even more unlikely recombinations possibly generating replication competent MLV viruses. Thus, utilization of the rat VL30 Psi sequence should improve the biological safety of MLV derived vectors for human gene transfer.

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Year:  1992        PMID： 1324044

Source DB:  PubMed          Journal:  Bone Marrow Transplant        ISSN： 0268-3369            Impact factor:   5.483


  2 in total

1.  RNA sequences in the Moloney murine leukemia virus genome bound by the Gag precursor protein in the yeast three-hybrid system.

Authors:  Matthew J Evans; Eran Bacharach; Stephen P Goff
Journal:  J Virol       Date:  2004-07       Impact factor: 5.103

2.  A small and efficient dimerization/packaging signal of rat VL30 RNA and its use in murine leukemia virus-VL30-derived vectors for gene transfer.

Authors:  C Torrent; C Gabus; J L Darlix
Journal:  J Virol       Date:  1994-02       Impact factor: 5.103
  2 in total

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