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Literature DB >> 1323958

Relative beta-lactamase- and transpeptidase-inhibitory activities of the new quinolone WIN-57273 in Staphylococcus aureus.

Abstract

The new quinolone WIN-57273 was shown to inhibit Staphylococcus aureus beta-lactamase activity noncompetitively in vitro with an apparent Ki value of 0.5 mM. MICs of penicillin G for a highly quinolone-resistant, beta-lactamase-negative strain in the presence of exogenous beta-lactamase decreased considerably when subinhibitory concentrations of WIN-57273 were added. Furthermore, the attachment transpeptidase reaction, investigated on whole cells of S. aureus, was impeded by WIN-57273 concentrations of greater than or equal to 30 microM. While these interactions suggest a novel mechanism of action for this compound, they are probably not relevant to the overall antibacterial potency of WIN-57273.

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Year: 1992 PMID： 1323958 PMCID： PMC189483 DOI： 10.1128/AAC.36.4.894

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

12 in total

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Journal: Eur J Clin Microbiol Date: 1986-12 Impact factor: 3.267

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Journal: FEBS Lett Date: 1987-08-31 Impact factor: 4.124

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Journal: Antimicrob Agents Chemother Date: 1989-12 Impact factor: 5.191

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Journal: J Antimicrob Chemother Date: 1990-10 Impact factor: 5.790

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Journal: Eur J Biochem Date: 1989-10-20