Literature DB >> 1323480

Trans-ACPD inhibits cAMP formation via a pertussis toxin-sensitive G-protein.

O Manzoni1, L Prezeau, F Sladeczek, J Bockaert.   

Abstract

In primary cultured striatal neurons we found that (+-)-trans-1-amino-cyclopentyl-1,3-dicarboxylate (trans-ACPD) could inhibit forskolin-induced cAMP formation in a dose-dependent manner (EC50 156 +/- 38 microM, n = 5, maximal inhibition 37.8 +/- 1.2, n = 37). The trans-ACPD-induced inhibition was totally abolished in neurons preincubated with Bordetella pertussis toxin (1 microgram/ml), demonstrating the involvement of a G-protein. This is the first report in intact neurons of a glutamate metabotropic receptor negatively coupled to cAMP formation.

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Year:  1992        PMID： 1323480     DOI： 10.1016/0922-4106(92)90112-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

1.  Characterization of a metabotropic glutamate receptor: direct negative coupling to adenylyl cyclase and involvement of a pertussis toxin-sensitive G protein.

Authors:  L Prezeau; O Manzoni; V Homburger; F Sladeczek; K Curry; J Bockaert
Journal:  Proc Natl Acad Sci U S A       Date:  1992-09-01       Impact factor: 11.205

2.  Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis.

Authors:  Kristen A Rahn; Crystal C Watkins; Jesse Alt; Rana Rais; Marigo Stathis; Inna Grishkan; Ciprian M Crainiceau; Martin G Pomper; Camilo Rojas; Mikhail V Pletnikov; Peter A Calabresi; Jason Brandt; Peter B Barker; Barbara S Slusher; Adam I Kaplin
Journal:  Proc Natl Acad Sci U S A       Date:  2012-11-19       Impact factor: 11.205

3.  Role of p/q-Ca2+ channels in metabotropic glutamate receptor 2/3-dependent presynaptic long-term depression at nucleus accumbens synapses.

Authors:  David Robbe; Gerard Alonso; Severine Chaumont; Joel Bockaert; Olivier J Manzoni
Journal:  J Neurosci       Date:  2002-06-01       Impact factor: 6.167

4.  Pharmacological characterization of the metabotropic glutamate receptor inhibiting D-[3H]-aspartate output in rat striatum.

Authors:  G Lombardi; M Alesiani; P Leonardi; G Cherici; R Pellicciari; F Moroni
Journal:  Br J Pharmacol       Date:  1993-12       Impact factor: 8.739

5.  Protein kinase C and A3 adenosine receptor activation inhibit presynaptic metabotropic glutamate receptor (mGluR) function and uncouple mGluRs from GTP-binding proteins.

Authors:  T A Macek; H Schaffhauser; P J Conn
Journal:  J Neurosci       Date:  1998-08-15       Impact factor: 6.167

6.  Glutamate, learning and dementia-selection of evidence.

Authors:  W Danysz; T Archer
Journal:  Amino Acids       Date:  1994-06       Impact factor: 3.520

7.  Elevated intracranial dopamine impairs the glutamate‑nitric oxide‑cyclic guanosine monophosphate pathway in cortical astrocytes in rats with minimal hepatic encephalopathy.

Authors:  Saidan Ding; Weilong Huang; Yiru Ye; Jianjing Yang; Jiangnan Hu; Xiaobin Wang; Leping Liu; Qin Lu; Yuanshao Lin
Journal:  Mol Med Rep       Date:  2014-07-16       Impact factor: 2.952
  7 in total

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