Literature DB >> 1323466

High performance liquid chromatography and preliminary pharmacokinetics of rufloxacin and its metabolites N-desmethylrufloxacin and rufloxacinsulfoxide in plasma and urine of humans.

T B Vree1, M van den Biggelaar-Martea, B P Imbimbo.   

Abstract

An HPLC analysis was developed for the measurement of rufloxacin and two of its possible metabolites N-desmethylrufloxacin and rufloxacinsulfoxide. Humans are unable to form these two metabolites, while no other metabolites could be detected in the HPLC chromatogram. The half-life of elimination of rufloxacin in two human subjects was 27 and 38 h respectively, while a constant percentage of 25-26% of the dose is excreted unchanged in the urine.

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Year:  1992        PMID： 1323466     DOI： 10.1007/BF03189987

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  7 in total

1.  The metabolism of ofloxacin in humans.

Authors:  F A Wong; S C Flor
Journal:  Drug Metab Dispos       Date:  1990 Nov-Dec       Impact factor: 3.922

2.  Inter- and intrasubject variabilities in the pharmacokinetics of rufloxacin after single oral administration to healthy volunteers.

Authors:  B P Imbimbo; G Broccali; M Cesana; F Crema; G Attardo-Parrinello
Journal:  Antimicrob Agents Chemother       Date:  1991-02       Impact factor: 5.191

3.  Steady-state kinetics of the quinolone derivatives ofloxacin, enoxacin, ciprofloxacin and pefloxacin during maintenance treatment with theophylline.

Authors:  W J Wijnands; T B Vree; A M Baars; C L van Herwaarden
Journal:  Drugs       Date:  1987       Impact factor: 9.546

4.  Quinolonecarboxylic acids. 2. Synthesis and antibacterial evaluation of 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzothiazine-6-carboxylic acids.

Authors:  V Cecchetti; A Fravolini; R Fringuelli; G Mascellani; P Pagella; M Palmioli; G Segre; P Terni
Journal:  J Med Chem       Date:  1987-03       Impact factor: 7.446

5.  A new tricyclic fluoroquinolone, rufloxacin (MF-934), with interesting antibacterial and pharmacokinetic characteristics.

Authors:  G Segre; D Cerretani; D Cerri; L Moltoni
Journal:  Drugs Exp Clin Res       Date:  1988

6.  Rufloxacin (MF-934): in vitro and in vivo antibacterial activity.

Authors:  G Ravizzola; G Pinsi; F Pirali; D Colombrita; I Foresti; L Peroni; A Turano
Journal:  Drugs Exp Clin Res       Date:  1989

7.  High-performance liquid chromatography and preliminary pharmacokinetics of rufloxacin and its metabolites, N-desmethylrufloxacin and rufloxacinsulfoxide, in urine of rhesus monkey Macaca mulatta.

Authors:  T B Vree; M van den Biggelaar-Martea; A Peeters; B P Imbimbo
Journal:  J Chromatogr       Date:  1992-01-03
  7 in total

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