| Literature DB >> 1322690 |
P L Tazzari1, A Bolognesi, D de Totero, B Falini, R M Lemoli, M R Soria, S Pileri, M Gobbi, H Stein, L Flenghi.
Abstract
An immunotoxin containing an anti-CD30 monoclonal antibody (Ber-H2) and saporin, a ribosome-inactivating protein type 1, is described. It specifically inhibits protein synthesis by Hodgkin derived target cell lines with a very high efficiency (IC50 ranging from 5 x 10(-12) M to 5 x 10(-14) M, as saporin), while irrelevant immunotoxins do not. Present results suggest that this immunotoxin could be used for in vivo therapy as well as for ex vivo bone marrow purging in Hodgkin's disease and CD30+ lymphomas.Entities:
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Year: 1992 PMID： 1322690 DOI： 10.1111/j.1365-2141.1992.tb08208.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998