Literature DB >> 1321789

The expression of the EBV latent membrane protein (LMP-1) is independent of CD23 and bcl-2 in Reed-Sternberg cells in Hodgkin's disease.

A A Armstrong1, A Gallagher, A S Krajewski, D B Jones, B S Wilkins, D E Onions, R F Jarrett.   

Abstract

A series of 33 cases of Hodgkin's disease was investigated for the presence of the EBV encoded latent gene product LMP-1 and of CD23 using immunohistochemical techniques. The expression of bcl-2 was examined in a subset of cases. LMP-1 was detected in the Reed-Sternberg cells in 15 cases. Although LMP-1 is known to upregulate CD23 and bcl-2, there was no correlation between the expression of LMP-1 and the detection of CD23 and bcl-2 in Reed-Sternberg cells.

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Year:  1992        PMID: 1321789     DOI: 10.1111/j.1365-2559.1992.tb00346.x

Source DB:  PubMed          Journal:  Histopathology        ISSN: 0309-0167            Impact factor:   5.087


  5 in total

1.  Epstein-Barr virus infection and bcl-2 proto-oncogene expression. Separate events in the pathogenesis of Hodgkin's disease?

Authors:  G Khan; R K Gupta; P J Coates; G Slavin
Journal:  Am J Pathol       Date:  1993-11       Impact factor: 4.307

2.  Lack of correlation between expression of Epstein-Barr virus (EBV) latent membrane protein and bcl-2 oncoprotein in vivo.

Authors:  Q Tao; G Srivastava; S L Loke; F C Ho
Journal:  J Clin Pathol       Date:  1994-07       Impact factor: 3.411

3.  CD40 expression in Hodgkin's disease.

Authors:  J T O'Grady; S Stewart; J Lowrey; S E Howie; A S Krajewski
Journal:  Am J Pathol       Date:  1994-01       Impact factor: 4.307

Review 4.  Gamma herpesviruses: pathogenesis of infection and cell signaling.

Authors:  J Rajcáni; M Kúdelová
Journal:  Folia Microbiol (Praha)       Date:  2003       Impact factor: 2.099

5.  Association of Epstein-Barr virus with pediatric Hodgkin's disease.

Authors:  A A Armstrong; F E Alexander; R P Paes; N A Morad; A Gallagher; A S Krajewski; D B Jones; B Angus; J Adams; R A Cartwright
Journal:  Am J Pathol       Date:  1993-06       Impact factor: 4.307

  5 in total

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