Literature DB >> 1321495

Phosphorylation-independent modulation of L-type calcium channels by magnesium-nucleotide complexes.

B O'Rourke1, P H Backx, E Marban.   

Abstract

Free magnesium ions and magnesium-nucleotide complexes can exert opposite effects on many fundamental cellular processes. Although increases in the intracellular concentration of magnesium ions inhibit the L-type calcium current in heart cells, magnesium-adenosine triphosphate complexes (MgATP) would be expected to increase the current by promoting channel phosphorylation. Rapid increases in the intracellular concentration of MgATP induced by flash photolysis of caged magnesium or caged ATP resulted in enhanced calcium current. The increase in calcium current was not prevented by blocking phosphorylation, revealing a previously unrecognized direct regulatory action of the magnesium-nucleotide complex.

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Year:  1992        PMID： 1321495     DOI： 10.1126/science.1321495

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  30 in total

1.  A zinc-dependent Cl- current in neuronal somata.

Authors:  T Tabata; A T Ishida
Journal:  J Neurosci       Date:  1999-07-01       Impact factor: 6.167

2.  Calpastatin domain L is a partial agonist of the calmodulin-binding site for channel activation in Cav1.2 Ca2+ channels.

Authors:  Etsuko Minobe; Hadhimulya Asmara; Zahangir A Saud; Masaki Kameyama
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Review 3.  Regulation of L-type Ca2+ channels in the heart: overview of recent advances.

Authors:  Kaoru Yamaoka; Masaki Kameyama
Journal:  Mol Cell Biochem       Date:  2003-11       Impact factor: 3.396

Review 4.  Regulation of ion channels in myocardial cells and protection of ischemic myocardium.

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Journal:  Heart Fail Rev       Date:  2000-06       Impact factor: 4.214

5.  Protein kinase C requirement of Ca2+ channel stimulation by intracellular ATP in guinea-pig basilar artery smooth muscle cells.

Authors:  D McHugh; D J Beech
Journal:  J Physiol       Date:  1997-04-15       Impact factor: 5.182

6.  Modulation of Ca2+ channel activity by ATP metabolism and internal Mg2+ in guinea-pig basilar artery smooth muscle cells.

Authors:  D McHugh; D J Beech
Journal:  J Physiol       Date:  1996-04-15       Impact factor: 5.182

7.  Dynamic modulation of Ca2+ sparks by mitochondrial oscillations in isolated guinea pig cardiomyocytes under oxidative stress.

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8.  Membrane-Delimited Phosphorylation Enables the Activation of the Outward-Rectifying K Channels in Motor Cell Protoplasts of Samanea saman.

Authors:  N. Moran
Journal:  Plant Physiol       Date:  1996-08       Impact factor: 8.340

9.  A comparative analysis of the time course of cardiac Ca2+ current response to rapid applications of beta-adrenergic and dihydropyridine agonists.

Authors:  P F Méry; A M Frace; H C Hartzell; R Fischmeister
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-08       Impact factor: 3.000

10.  Suppression of GABAA receptor responses by NMDA application in hippocampal neurones acutely isolated from the adult guinea-pig.

Authors:  Q X Chen; R K Wong
Journal:  J Physiol       Date:  1995-01-15       Impact factor: 5.182
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