Literature DB >> 1321227

Conservation of HPV-16 E6/E7 ORF sequences in a cervical carcinoma.

R W Cone1, A C Minson, M R Smith, J K McDougall.   

Abstract

A cervical carcinoma that contained human papillomavirus (HPV)-16 homologous DNA was analyzed. Each tumor cell genome contained a single, incomplete copy of HPV-16 DNA. The E6 and E7 open reading frames (ORFs) were completely conserved relative to other published HPV-16 sequences. Much of the non-coding region (NCR) was free of base changes, including complete conservation of several regulatory elements. Multiple mutations were identified in the remaining integrated HPV-16 DNA, which was composed of parts of the L1 and E1 ORFs. The extraordinary conservation of the E6/E7 DNA sequence, as compared with other regions of the integrated HPV-16 DNA, supports the role of E6/E7 in tumorigenesis.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1321227     DOI： 10.1002/jmv.1890370205

Source DB:  PubMed          Journal:  J Med Virol        ISSN： 0146-6615            Impact factor:   2.327


  3 in total

1.  Tobacco exposure results in increased E6 and E7 oncogene expression, DNA damage and mutation rates in cells maintaining episomal human papillomavirus 16 genomes.

Authors:  Lanlan Wei; Anastacia M Griego; Ming Chu; Michelle A Ozbun
Journal:  Carcinogenesis       Date:  2014-07-26       Impact factor: 4.944

2.  Small tumor virus genomes are integrated near nuclear matrix attachment regions in transformed cells.

Authors:  K A Shera; C A Shera; J K McDougall
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

3.  Absence of human papillomavirus genomic sequences detected by the polymerase chain reaction in oesophageal and gastric carcinomas in Japan.

Authors:  M Saegusa; M Hashimura; Y Takano; M Ohbu; I Okayasu
Journal:  Mol Pathol       Date:  1997-04
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.