Literature DB >> 1320585

Insertional inactivation of a gene which controls expression of vancomycin resistance on plasmid pHKK100.

S Handwerger1, L Discotto, J Thanassi, M J Pucci.   

Abstract

Expression of inducible high level vancomycin resistance (Vmr) in enterococci appears to require other plasmid-encoded genes in addition to the previously described structural genes vanA and vanH. Tn917 mutagenesis was used to identify such a region in the Vmr plasmid pHKK100. Insertional inactivation of a 693-bp open reading frame upstream from vanH resulted in complete loss of Vmr. This putative 26,642-Da protein has been designated VanR.

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Year:  1992        PMID： 1320585     DOI： 10.1016/0378-1097(92)90533-t

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  9 in total

Review 1.  Current perspectives on glycopeptide resistance.

Authors:  N Woodford; A P Johnson; D Morrison; D C Speller
Journal:  Clin Microbiol Rev       Date:  1995-10       Impact factor: 26.132

2.  Heterogeneity of the vanA gene cluster in clinical isolates of enterococci from the northeastern United States.

Authors:  S Handwerger; J Skoble; L F Discotto; M J Pucci
Journal:  Antimicrob Agents Chemother       Date:  1995-02       Impact factor: 5.191

Review 3.  Genetics and mechanisms of glycopeptide resistance in enterococci.

Authors:  M Arthur; P Courvalin
Journal:  Antimicrob Agents Chemother       Date:  1993-08       Impact factor: 5.191

4.  Identification of chromosomal mobile element conferring high-level vancomycin resistance in Enterococcus faecium.

Authors:  S Handwerger; J Skoble
Journal:  Antimicrob Agents Chemother       Date:  1995-11       Impact factor: 5.191

5.  The VanS sensor negatively controls VanR-mediated transcriptional activation of glycopeptide resistance genes of Tn1546 and related elements in the absence of induction.

Authors:  M Arthur; F Depardieu; G Gerbaud; M Galimand; R Leclercq; P Courvalin
Journal:  J Bacteriol       Date:  1997-01       Impact factor: 3.490

6.  Alterations in peptidoglycan precursors and vancomycin susceptibility in Tn917 insertion mutants of Enterococcus faecalis 221.

Authors:  S Handwerger
Journal:  Antimicrob Agents Chemother       Date:  1994-03       Impact factor: 5.191

7.  The cytoplasmic peptidoglycan precursor of vancomycin-resistant Enterococcus faecalis terminates in lactate.

Authors:  S Handwerger; M J Pucci; K J Volk; J Liu; M S Lee
Journal:  J Bacteriol       Date:  1992-09       Impact factor: 3.490

8.  Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147.

Authors:  M Arthur; C Molinas; F Depardieu; P Courvalin
Journal:  J Bacteriol       Date:  1993-01       Impact factor: 3.490

9.  Systematic inactivation and phenotypic characterization of two-component signal transduction systems of Enterococcus faecalis V583.

Authors:  Lynn E Hancock; Marta Perego
Journal:  J Bacteriol       Date:  2004-12       Impact factor: 3.490
  9 in total

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