Literature DB >> 1320389

A new liver functional study using Tc-99m DTPA-galactosyl human serum albumin: evaluation of the validity of several functional parameters.

K Koizumi1, G Uchiyama, T Arai, T Ainoda, Y Yoda.   

Abstract

Several parameters calculated with a new functional imaging agent for the liver, Tc-99m DTPA-galactosyl human serum albumin, were evaluated in 9 patients with liver cirrhosis, one with hepatocellular carcinoma, and five with both liver cirrhosis and hepatocellular carcinoma. LU3, which represents the cumulative uptake of the tracer from 3 to 4 minutes after injection, showed a strong correlation (r = 0.858, p = 0.0001) with LHL15, which represents the count ratio for the liver to sum for the liver and heart 15 minutes after injection of the tracer. It also showed a strong correlation (r = -0.896, p = 0.0001) with the indocyanine green retention rate (ICGR15). Regional ICGR15 is therefore calculable from the regional LU3. GSAR15, which represents the radioactivity of the tracer retained in the blood 15 minutes after injection, showed a strong correlation (r = 0.878, p = 0.0001) with HH15, which represents the count ratio for the heart 15 minutes after injection of the tracer divided by the count for the heart 3 minutes after injection. In conclusion, LU3 and GSAR15 are interesting and promising parameters for assessing liver function.

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Year:  1992        PMID： 1320389     DOI： 10.1007/bf03164647

Source DB:  PubMed          Journal:  Ann Nucl Med        ISSN： 0914-7187            Impact factor:   2.668


  10 in total

1.  [Phase II clinical study on 99mTc-GSA, a new agent for functional imaging of the liver].

Authors:  K Torizuka; S K Ha-Kawa; M Kudo; S Kitagawa; Y Kubota; Y Tanaka; M Hino; K Ikekubo
Journal:  Kaku Igaku       Date:  1992-01

2.  Clinical application of the measurement of serum asialoglycoproteins to estimate residual liver function in patients with chronic liver diseases with or without hepatocellular carcinoma.

Authors:  T Sawamura; S Kawasato; M Tsuda; Y Naitoh; Y Shiozaki; Y Sameshima
Journal:  Gastroenterol Jpn       Date:  1985-06

3.  [Estimation of hepatic functional reserve by asialoglycoprotein receptor-binding, radiolabeled synthetic ligand Tc-99m-galactosyl-neoglycoalbumin--preclinical and clinical studies].

Authors:  M Kudo; A Todo; K Ikekubo; M Hino; H Ito; H Yamaguchi; Y Saiki; K Yamamoto; Y Yonekura; K Torizuka
Journal:  Kaku Igaku       Date:  1987-11

4.  [A new liver function test using the asialoglycoprotein-receptor system on the liver cell membrane: III. Evaluation of its usefulness by a liver function test using Tc-99m-neoglycoprotein].

Authors:  H Hazama; S Kawa; Y Kubota; M Kojima; T Murase; H Okuno; Y Naitoh; Y Nishiyama; K Washino; T Hasegawa
Journal:  Kaku Igaku       Date:  1986-07

5.  Validation of in vivo receptor measurements via in vitro radioassay: technetium-99m-galactosyl-neoglycoalbumin as prototype model.

Authors:  M Kudo; D R Vera; W L Trudeau; R C Stadalnik
Journal:  J Nucl Med       Date:  1991-06       Impact factor: 10.057

6.  Measurement of receptor concentration and forward-binding rate constant via radiopharmacokinetic modeling of technetium-99m-galactosyl-neoglycoalbumin.

Authors:  D R Vera; R C Stadalnik; W L Trudeau; P O Scheibe; K A Krohn
Journal:  J Nucl Med       Date:  1991-06       Impact factor: 10.057

7.  [Dose estimation of Tc-99m-DTPA-galactosyl-human serum albumin (Tc-99m-GSA) in the blood with nonlinear regression method].

Authors:  S K Ha-Kawa; M Kojima; Y Suga; H Kurokawa; Y Itagaki; Y Tanaka
Journal:  Kaku Igaku       Date:  1991-04

8.  Hyperasialoglycoproteinemia in patients with chronic liver diseases and/or liver cell carcinoma. Asialoglycoprotein receptor in cirrhosis and liver cell carcinoma.

Authors:  T Sawamura; H Nakada; H Hazama; Y Shiozaki; Y Sameshima; Y Tashiro
Journal:  Gastroenterology       Date:  1984-12       Impact factor: 22.682

9.  Tc-99m galactosyl-neoglycoalbumin: in vitro characterization of receptor-mediated binding.

Authors:  D R Vera; K A Krohn; R C Stadalnik; P O Scheibe
Journal:  J Nucl Med       Date:  1984-07       Impact factor: 10.057

10.  Technetium-99m NGA functional hepatic imaging: preliminary clinical experience.

Authors:  R C Stadalnik; D R Vera; E S Woodle; W L Trudeau; B A Porter; R E Ward; K A Krohn; L F O'Grady
Journal:  J Nucl Med       Date:  1985-11       Impact factor: 10.057
  10 in total
  12 in total

1.  Predictors of successful hepatic resection: prognostic usefulness of hepatic asialoglycoprotein receptor analysis.

Authors:  Norihiro Kokudo; David R Vera; Keiichiro Tada; Mitsuru Koizumi; Makoto Seki; Toshiki Matsubara; Hirotoshi Ohta; Toshiharu Yamaguchi; Takashi Takahashi; Toshifusa Nakajima; Tetsuichiro Muto
Journal:  World J Surg       Date:  2002-09-26       Impact factor: 3.352

2.  Assessment of liver function in primary biliary cirrhosis using Gd-EOB-DTPA-enhanced liver MRI.

Authors:  Henrik Nilsson; Lennart Blomqvist; Lena Douglas; Anders Nordell; Eduard Jonas
Journal:  HPB (Oxford)       Date:  2010-10       Impact factor: 3.647

3.  Index of convexity: a novel liver function index using Tc-GSA scintigraphy.

Authors:  Kenji Miki; Yuichi Matsui; Masanori Teruya; Michio Kaminishi; Norihiro Kokudo
Journal:  World J Gastroenterol       Date:  2013-01-07       Impact factor: 5.742

4.  (99m)Tc-labeled porphyrin-lipid nanovesicles.

Authors:  Jae-Ho Lee; Shuai Shao; Kenneth T Cheng; Jonathan F Lovell; Chang H Paik
Journal:  J Liposome Res       Date:  2014-06-25       Impact factor: 3.648

5.  Remnant liver volume-based predictors of postoperative liver dysfunction after hepatectomy: analysis of 625 consecutive patients from a single institution.

Authors:  Hirohisa Okabe; Toru Beppu; Akira Chikamoto; Hiromitsu Hayashi; Morikatsu Yoshida; Toshiro Masuda; Katsunori Imai; Kosuke Mima; Shigeki Nakagawa; Hideyuki Kuroki; Hidetoshi Nitta; Takatoshi Ishiko; Daisuke Hashimoto; Yasuyuki Yamashita; Hideo Baba
Journal:  Int J Clin Oncol       Date:  2013-07-17       Impact factor: 3.402

6.  (99m)Tc-labeled therapeutic inhaled amikacin loaded liposomes.

Authors:  Jae-Ho Lee; Kenneth T Cheng; Vladimir Malinin; Zhili Li; Zhengsheng Yao; Sung-Jin Lee; Christine M Gould; Kenneth N Olivier; Clara Chen; Walter R Perkins; Chang H Paik
Journal:  J Liposome Res       Date:  2013-07-24       Impact factor: 3.648

Review 7.  ICG Clearance Test and 99mTc-GSA SPECT/CT Fusion Images.

Authors:  Yuji Iimuro
Journal:  Visc Med       Date:  2017-11-22

8.  Measuring hepatic functional reserve using low temporal resolution Gd-EOB-DTPA dynamic contrast-enhanced MRI: a preliminary study comparing galactosyl human serum albumin scintigraphy with indocyanine green retention.

Authors:  Kazuhiro Saito; Joseph Ledsam; Steven Sourbron; Tsuyoshi Hashimoto; Yoichi Araki; Soichi Akata; Koichi Tokuuye
Journal:  Eur Radiol       Date:  2013-08-15       Impact factor: 5.315

Review 9.  Evaluation of Liver Function and the Role of Biliary Drainage before Major Hepatic Resections.

Authors:  Yuzo Yamamoto
Journal:  Visc Med       Date:  2020-12-11

10.  Predicting hepatic failure with a new diagnostic technique by preoperative liver scintigraphy and computed tomography: a pilot study in 123 patients undergoing liver resection.

Authors:  Naokazu Chiba; Motohide Shimazu; Kiminori Takano; Go Oshima; Koichi Tomita; Toru Sano; Masaaki Okihara; Yosuke Ozawa; Kosuke Hikita; Takahiro Gunji; Yuta Abe; Kiyoshi Koizumi; Shigeyuki Kawachi
Journal:  Patient Saf Surg       Date:  2017-12-18
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