Literature DB >> 1319906

5-Hydroxytryptamine stimulates cyclic AMP formation in the tunica muscularis mucosae of the rat oesophagus via 5-HT4 receptors.

A P Ford1, G S Baxter, R M Eglen, D E Clarke.   

Abstract

The nature of 5-HT4 receptor coupling in the tunica muscularis mucosae of the rat oesophagus has been studied. 5-HT and renzapride stimulated cyclic AMP formation concentration dependently, with -log EC50 values of 7.1 and 6.8, respectively. Renzapride, relative to 5-HT, acted as a partial agonist. Tropisetron (ICS 205 930) and a novel 5-HT4 antagonist, SDZ 205 557, inhibited 5-HT-induced cyclic AMP production competitively, with pA2 estimates of 6.7 and 7.7, respectively. These data are consistent with the hypothesis that 5-HT4 receptors mediate relaxation of the smooth muscle cells of the tunica muscularis mucosae of rat oesophagus via activation of adenylyl cyclase.

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Year:  1992        PMID： 1319906     DOI： 10.1016/0014-2999(92)90272-6

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  11 in total

1.  5-HT4 receptor mediated stimulation of gastric emptying in rats.

Authors:  S S Hegde; A G Wong; M R Perry; P Ku; T M Moy; M Loeb; R M Eglen
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-06       Impact factor: 3.000

2.  A comparative study of functional 5-HT4 receptors in human colon, rat oesophagus and rat ileum.

Authors:  P G McLean; I M Coupar; P Molenaar
Journal:  Br J Pharmacol       Date:  1995-05       Impact factor: 8.739

3.  Functional interactions between muscarinic M2 receptors and 5-hydroxytryptamine (5-HT)4 receptors and beta 3-adrenoceptors in isolated oesophageal muscularis mucosae of the rat.

Authors:  R M Eglen; B Peelle; M T Pulido-Rios; E Leung
Journal:  Br J Pharmacol       Date:  1996-10       Impact factor: 8.739

Review 4.  Role of the serotonergic system in the neurobiology of alcoholism: implications for treatment.

Authors:  Bankole A Johnson
Journal:  CNS Drugs       Date:  2004       Impact factor: 5.749

5.  Characterization of the 5-HT4 receptor mediating tachycardia in piglet isolated right atrium.

Authors:  A D Medhurst; A J Kaumann
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

6.  Comparison of 5-HT4 receptors in guinea-pig colon and rat oesophagus: effects of novel agonists and antagonists.

Authors:  E Leung; M T Pulido-Rios; D W Bonhaus; L A Pekins; K D Zeitung; S A Hsu; R D Clark; E H Wong; R M Eglen
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996-07       Impact factor: 3.000

7.  5-HT decreases contractile and electrical activities in lymphatic vessels of the guinea-pig mesentery: role of 5-HT 7-receptors.

Authors:  Alice K Chan; Pierre-Yves von der Weid
Journal:  Br J Pharmacol       Date:  2003-05       Impact factor: 8.739

8.  Development of a radioligand binding assay for 5-HT4 receptors in guinea-pig and rat brain.

Authors:  C J Grossman; G J Kilpatrick; K T Bunce
Journal:  Br J Pharmacol       Date:  1993-07       Impact factor: 8.739

9.  Evidence for an inhibitory 5-HT4 receptor in urinary bladder of rhesus and Cynomolgus monkeys.

Authors:  M V Waikar; A P Ford; D E Clarke
Journal:  Br J Pharmacol       Date:  1994-01       Impact factor: 8.739

10.  Further investigation into the signal transduction mechanism of the 5-HT4-like receptor in the circular smooth muscle of human colon.

Authors:  P G McLean; I M Coupar
Journal:  Br J Pharmacol       Date:  1996-06       Impact factor: 8.739
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