Literature DB >> 1319477

Chromosomal localization of human glutamate receptor genes.

J O McNamara1, J H Eubanks, J D McPherson, J J Wasmuth, G A Evans, S F Heinemann.   

Abstract

The chromosomal localization of human glutamate receptor genes (GluR1-4) has been established using PCR with DNA isolated from mapping panels of Chinese hamster-human hybrid cell lines and high-resolution fluorescent in situ suppression hybridization. This was accomplished with genomic clones containing putative human homologs of rat GluR 1-4 isolated by high-stringency screening of a cosmid library with the rat cDNAs encoding GluR1-4. The locations of GluR1-4, respectively, are 5q32-33, 4q32-33, Xq25-26, and 11q22-23. Evidence implicating glutamatergic synapses in a diversity of physiologic and pathologic processes together with concordance of the chromosomal locales and results of linkage analyses establishes GluR3 and GluR4 as candidate genes for a number of nervous system disorders including the oculocerebral-renal syndrome of Lowe and a form of manic-depressive illness.

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Year:  1992        PMID： 1319477      PMCID： PMC6575855     

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


  8 in total

Review 1.  Expression and regulation of kainate and AMPA receptors in uncommitted and committed neural progenitors.

Authors:  V Gallo; M Pende; S Scherer; M Molné; P Wright
Journal:  Neurochem Res       Date:  1995-05       Impact factor: 3.996

2.  The gene encoding the glutamate receptor subunit GluR5 is located on human chromosome 21q21.1-22.1 in the vicinity of the gene for familial amyotrophic lateral sclerosis.

Authors:  J H Eubanks; R S Puranam; N W Kleckner; B Bettler; S F Heinemann; J O McNamara
Journal:  Proc Natl Acad Sci U S A       Date:  1993-01-01       Impact factor: 11.205

3.  Genetic and physical mapping of the GLUR5 glutamate receptor gene on human chromosome 21.

Authors:  P Gregor; S M Gaston; X Yang; J P O'Regan; D R Rosen; R E Tanzi; D Patterson; J L Haines; H R Horvitz; G R Uhl
Journal:  Hum Genet       Date:  1994-11       Impact factor: 4.132

Review 4.  Glutamate receptor genes: susceptibility factors in schizophrenia and depressive disorders?

Authors:  Hans H Schiffer
Journal:  Mol Neurobiol       Date:  2002-04       Impact factor: 5.590

5.  Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.

Authors:  P Gregor; R H Reeves; E W Jabs; X Yang; W Dackowski; J M Rochelle; R H Brown; J L Haines; B F O'Hara; G R Uhl
Journal:  Proc Natl Acad Sci U S A       Date:  1993-04-01       Impact factor: 11.205

6.  Isolation and chromosomal localization of a human ATP-regulated potassium channel.

Authors:  S N Krishnan; T Desai; D C Ward; G G Haddad
Journal:  Hum Genet       Date:  1995-08       Impact factor: 4.132

7.  A genome-wide search for genes predisposing to manic-depression, assuming autosomal dominant inheritance.

Authors:  H Coon; S Jensen; M Hoff; J Holik; R Plaetke; F Reimherr; P Wender; M Leppert; W Byerley
Journal:  Am J Hum Genet       Date:  1993-06       Impact factor: 11.025

8.  The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat.

Authors:  C Szpirer; M Molné; R Antonacci; N A Jenkins; P Finelli; J Szpirer; M Riviere; M Rocchi; D J Gilbert; N G Copeland
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-06       Impact factor: 11.205
  8 in total

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