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Literature DB >> 131944

An experiment eliminating the rotating carrier mechanism for the active transport of Ca ion in sarcoplasmic reticulum membranes.

Abstract

An experiment has been carried out to test the rotating carrier mechanism of the translocation event in membrane transport. To the Ca-ATPase in intact sarcoplasmic reticulum membranes, 2,4-[3H]dinitrophenyl-cadaverine has been covalently attached by the action of the enzyme, transglutaminase. The binding of anti-2,4-dinitrophenyl antibodies to the 2,4-dinitrophenyl-modified membranes was found to have no effect on either the Ca-ATPase activity or the Ca ion transport rate of the membranes. These results rule out the rotating carrier mechanism in this system. A different scheme for the translocation process, the aggregate rearrangement mechanism, is discussed.

Entities: Chemical

Mesh：

Substances：

Year: 1976 PMID： 131944 PMCID： PMC430331 DOI： 10.1073/pnas.73.5.1532

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

25 in total

1. Structural studies of sodium and potassium ion-activated adenosine triphosphatase. The relationship between molecular structure and the mechanism of active transport.

Authors: J Kyte
Journal: J Biol Chem Date: 1975-09-25 Impact factor: 5.157

2. A coupling factor from sarcoplasmic reticulum required for the translocation of Ca2+ ions in a reconstituted Ca2+ATPase pump.

Authors: E Racker; E Eytan
Journal: J Biol Chem Date: 1975-09-25 Impact factor: 5.157

3. A membrane protein from human erythrocytes involved in anion exchange.

Authors: M K Ho; G Guidotti
Journal: J Biol Chem Date: 1975-01-25 Impact factor: 5.157

4. Properties of a reconstituted calcium pump.

Authors: A F Knowles; E Racker
Journal: J Biol Chem Date: 1975-05-10 Impact factor: 5.157

5. Crosslinking and labeling of membrane proteins by transglutaminase-catalyzed reactions.

Authors: A Dutton; S J Singer
Journal: Proc Natl Acad Sci U S A Date: 1975-07 Impact factor: 11.205

6. Sarcoplasmic reticulum. IV. Solubilization of microsomal adenosine triphosphatase.

Authors: A Martonosi
Journal: J Biol Chem Date: 1968-01-10 Impact factor: 5.157

7. Studies on the location and orientation of proteins in the sarcoplasmic reticulum.

Authors: D A Thorley-Lawson; N M Green
Journal: Eur J Biochem Date: 1973-12-17

8. The reactions of sodium and potassium ion-activated adenosine triphosphatase with specific antibodies. Implications for the mechanism of active transport.

Authors: J Kyte
Journal: J Biol Chem Date: 1974-06-10 Impact factor: 5.157

4. A passage saturation transfer paramagnetic resonance study of the rotational diffusion of the sarcoplasmic reticulum calcium-ATPase.

Authors: M D King; P J Quinn
Journal: J Bioenerg Biomembr Date: 1983-06 Impact factor: 2.945

An experiment eliminating the rotating carrier mechanism for the active transport of Ca ion in sarcoplasmic reticulum membranes.

1. Structural studies of sodium and potassium ion-activated adenosine triphosphatase. The relationship between molecular structure and the mechanism of active transport.

2. A coupling factor from sarcoplasmic reticulum required for the translocation of Ca2+ ions in a reconstituted Ca2+ATPase pump.

3. A membrane protein from human erythrocytes involved in anion exchange.

4. Properties of a reconstituted calcium pump.

5. Crosslinking and labeling of membrane proteins by transglutaminase-catalyzed reactions.

6. Sarcoplasmic reticulum. IV. Solubilization of microsomal adenosine triphosphatase.

7. Studies on the location and orientation of proteins in the sarcoplasmic reticulum.

8. The reactions of sodium and potassium ion-activated adenosine triphosphatase with specific antibodies. Implications for the mechanism of active transport.

9. The proteins of rabbit skeletal muscle sarcoplasmic reticulum.

10. Characterization of sarcoplasmic reticulum from skeletal muscle.

1. [Membrane pores, pore proteins and ion transport].

2. Large-scale rotational motions of proteins detected by electron paramagnetic resonance and fluorescence.

3. Rotational motion of the sarcoplasmic reticulum Ca2+-ATPase.

4. A passage saturation transfer paramagnetic resonance study of the rotational diffusion of the sarcoplasmic reticulum calcium-ATPase.

Review 5. Binding energy, conformational change, and the mechanism of transmembrane solute movements.

6. Identification of transmembrane bridging proteins in the plasma membrane of cultured mouse L cells.

7. Sarcoplasmic reticulum calcium pump: a model for Ca2+ binding and Ca2+-coupled phosphorylation.

8. Membrane structure and drug actions.

Review 9. Biomechanical model of the P-type ion pumps of the cell.

Review 10. Oligomeric structure and the anion transport function of human erythrocyte band 3 protein.