| Literature DB >> 1319394 |
F Galland1, A Karamysheva, M G Mattei, O Rosnet, S Marchetto, D Birnbaum.
Abstract
A new human gene encoding a putative receptor-type tyrosine kinase (RTK) was isolated by screening a placenta cDNA library with a mouse Flt3 probe. The deduced amino acid sequence of the intracellular region of the molecule showed that it was strongly related to the FLT1 and KDR/FLK1 gene products and to a lesser degree to members of the class III RTKs: FMS/CSF1R, PDGFRA/B, KIT, and FLT3. The gene was named FLT4. Cosmid clones of the mouse Flt4 gene were isolated. The human gene was localized to bands q34-q35 of chromosome 5, i.e., slightly telomeric to the CSF1R/PDGRFB tandem of genes, and the mouse homolog to chromosome 11, region A5-B1.Entities:
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Year: 1992 PMID： 1319394 DOI： 10.1016/0888-7543(92)90277-y
Source DB: PubMed Journal: Genomics ISSN： 0888-7543 Impact factor: 5.736